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This review discusses recent advancements made in using mouse models to investigate the genetic complexity and pathogenesis of alopecia areata, emphasizing potential new treatment targets, but it reports no new findings.

In a mouse model study, researchers found that mutations in Aire reduced alopecia areata frequency, while Notch4 mutations did not lead to the disease, likely due to proximity with a resistance gene.

This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.

This study developed a method to quantify hair loss in mice, aiding the evaluation of new treatments for alopecia.

This review discusses the evaluation of animal models for hair research and regeneration, highlighting their importance and limitations, and calls for improved approaches to advance understanding of human hair diseases.