research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-Diene or 4,6-Diene 20-Ones and 4-Azasteroid 20-Oximes
Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.
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research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition
The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.
research Synthesis and Actions of 5α-Reduced Metabolites of Testosterone in the Nervous System
Testosterone and its metabolites affect brain functions and could help treat neurological disorders.
research The Implication of Neuroactive Steroids in Tourette's Syndrome Pathogenesis: A Role for 5α-Reductase?
Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.
research The Influence of Low Dose Finasteride, a Type II 5α-Reductase Inhibitor, on Circulating Neuroactive Steroids
Low dose finasteride decreases certain steroids, possibly increasing depression risk.
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