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Copper treatments increase copper in all tissues, but brindled female mice accumulate much more copper in their kidneys without clinical effects, unlike brindled male mice where brain copper deficiency is clinically significant.

Brindled mice show abnormal catecholamine neuron development due to copper deficiency.

Copper injections improved symptoms and prevented brain damage in brindled mice.

Cupric chloride treatment corrected abnormal Purkinje cell development in brindled mice.

Copper therapy improved health and enzyme activity in mice with copper deficiency.