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research 354 Investigating early molecular changes in a model of x-ray radiation-induced alopecia: spotlight on growth arrest and endothelial dysfunction

November 2025 in “Journal of Investigative Dermatology”

Radiation-induced hair loss may be caused by hair growth stopping and inflammation in blood vessels.

research Lean Women with Polycystic Ovary Syndrome

1 citations , February 2018 in “InTech eBooks”

This paper discusses the need for comprehensive evaluation and management of lean polycystic ovary syndrome patients due to their unique risks, but reports no new results.

research La voie de la PGI2 pour améliorer la cicatrisation des plaies du pied diabétique

March 2022

This study found changes in the PGI2 pathway, especially in gene and protein expression, in diabetic mice, but did not observe PGI2-dependent vasomotor dysfunction.

research Effect of Diurnal Blood Pressure on Endothelial Functions in Essential Hypertensive Patients

October 2013 in “Journal of the American College of Cardiology”

Blood pressure that doesn't drop at night is linked to worse blood vessel function in people with high blood pressure.

A Proposed Etiopathology of Persistent Dysfunctions Emerging from Use and Discontinuation of 5-Alpha Reductase Inhibitors: Sequelae of Drug-Mediated Microvasculopathy

research A proposed etiopathology of persistent dysfunctions emerging from use and discontinuation of 5-alpha reductase inhibitors: sequelae of drug-mediated microvasculopathy

February 2022

This hypothesis paper suggests that sexual and cognitive dysfunctions reported by some men after using finasteride and dutasteride may stem from vascular and tissue changes in penile tissue triggering broader inflammatory effects.

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Community Join

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community Scientists have found that a naturally occurring sugar in humans and animals could be used as a topical treatment for male pattern baldness | In the study, mice received 2dDR-SA gel for 21 days, resulting in greater number of blood vessels and an increase in hair follicle length and denseness

644 upvotes 2 years ago

Scientists discovered a sugar gel, 2dDR-SA, that increased hair growth in mice. Users discussed its potential, comparing it to other treatments like Minoxidil and finasteride.

community Control your blood pressure - for me this was my root issue

9 upvotes 1 year ago

Managing blood pressure can help with hair loss, as seen with the use of medications like Cialis and oral minoxidil, which improved hairline and blood pressure. Lifestyle changes, such as reducing stimulant use and adjusting testosterone replacement therapy (TRT) doses, also play a role in addressing hair loss and overall health.

community Dental technician is convinced that he has found the cause of pattern hair loss

314 upvotes 2 years ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community Trying to understand finasteride side effects and post finasteride syndrome

70 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community Just received my 2 Deoxy D Ribose wish me luck🫡

245 upvotes 2 years ago

A user is trying 2-deoxy-D-ribose with distilled water for hair growth, observing new hair and skin pigmentation changes. Others compare it to Minoxidil, expressing interest and caution about its effectiveness and safety.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Vascular Endothelial Growth Factor

How does Vascular Endothelial Growth Factor (VEGF) differ from DHT-blocking treatments for androgenic alopecia? VEGF promotes blood vessel growth, while DHT-blocking treatments reduce hormone effects on hair follicles.

learn capsicum

How does capsicum improve scalp circulation and boost growth? Capsaicin dilates blood vessels through TRPV1 activation, so capsicum is expected to raise scalp blood flow, but every human hair-loss study used it inside a multi-ingredient formula — and the strongest one gave it orally, not on the scalp — so its effect on hair by itself is unproven, and it is a known skin irritant.

learn Platelet-Rich Plasma

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

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