research Dual Aspects of B Cells in Tumor Immunity: Positive and Negative Regulation Against B16 Melanoma
B cells can both help and hinder the body's defense against melanoma.
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5 / 11 results research IMMUNOLOGICAL AND GENETIC ASPECTS OF HEREDITARY ANTIBODY DEFICIENCIES
The study focused on analyzing data from pediatric and adult patients diagnosed with Antibody Deficiencies (AD) at a PID center between 2010-2019. A total of 46 patients were identified with AD, including 3 adults and 6 children aged 2-8 years with sIgA deficiency, and 2 children aged 1-2 years with Hyper IgM syndrome. The largest group consisted of patients with common variable immune deficiency and agammaglobulinemia. Patients experienced frequent severe infections and received IVIG replacement therapy. Genetic tests revealed mutations in 5 patients: 2 with Btk deficiency, 2 with CD40 LG deficiency, and 1 with a BLNK gene mutation. The study concluded that children with repeated severe bacterial infections and hypoglobulinemia should be suspected of having PID, particularly AD, and recommended immune examinations including serum immunoglobulin levels and B and T-cell subsets as initial detection steps.
research The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation
Certain flavonoids can improve the growth of pigmented hair in mice.
research Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2
Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.
research SYK Inhibitor Entospletinib Prevents Ocular and Skin GVHD in Mice
Entospletinib effectively prevents eye and skin GVHD in mice.
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