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GlossaryBiotransformation

process of chemically altering substances in the body

Biotransformation is the process by which the body chemically alters substances, such as drugs or toxins, to make them easier to eliminate. This typically occurs in the liver and involves enzymatic reactions that convert these substances into more water-soluble compounds, facilitating their excretion through urine or bile.

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research The 39th Manfred Donike Workshop on Doping Analysis

1 citations, November 2021 in “Drug Testing and Analysis”

The 39th Manfred Donike Workshop discussed methods for detecting misuse of steroids, gene doping, and the complexity of identifying drug residues in urine, highlighting the ongoing efforts to improve global anti-doping work.

research Applications of Steroid Drugs Entrapped in Cyclodextrins

23 citations, March 2019 in “Environmental Chemistry Letters”

Cyclodextrins improve how steroid drugs work and are used in marketed medications and environmental applications.

research Metabolic Study of Androsta-1,4,6-Triene-3,17-Dione in Horses Using Liquid Chromatography/High Resolution Mass Spectrometry

17 citations, August 2015 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

The study found that urine metabolites M1b or M4 are the best indicators of ATD use in horses, with detection possible up to 77 hours in urine and 28 hours in blood.

Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

research Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

16 citations, October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

research In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

13 citations, January 2015 in “Toxicology Letters”

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

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