121 citations
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December 2001 in “American Journal of Dermatopathology” This study found that trichoblastomas and nodular basal cell carcinomas have similar cytokeratin expression patterns, indicating differentiation towards the outer root sheath epithelium.
107 citations
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May 1999 in “Archives of Dermatological Research” In this study, the immunohistochemical and lectin binding profiles of basal cell carcinoma closely resembled those of the outer root sheath of vellus hair follicles, suggesting a potential histochemical relationship.
551 citations
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November 2013 in “Nature” This study found that differentiated airway epithelial cells can revert into functional stem cells in vivo, suggesting a more general role for this dedifferentiation process in tissue regeneration in higher vertebrates.
This study found that basal cell carcinoma exhibits patterns of hair follicle differentiation but is stuck in telogen arrest, which can be rescued by adding noggin and TGF-β2 in vitro.
12 citations
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January 1987 in “Carcinogenesis” This study found that a single application of TCDD on the skin of hairless mice altered epidermal differentiation, changing keratin expression patterns similarly to a known tumor promoter.