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research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

380 citations , March 2000 in “Proceedings of the National Academy of Sciences”

This study demonstrates that mice with ectopic expression of the human GLI-1 gene in their skin developed tumors resembling human basal cell carcinoma, suggesting that GLI-1 is central to tumor development without additional p53 or Ha ras mutations.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.

research Identification of the cell lineage at the origin of basal cell carcinoma

351 citations , February 2010 in “Nature Cell Biology”

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

333 citations , March 2000 in “Proceedings of the National Academy of Sciences”

In this study, researchers established that increased expression of the human GLI-1 gene in mouse skin leads to the development of tumors that closely resemble human basal cell carcinomas, without requiring additional mutations in the p53 or Ha ras genes.

research Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas.

277 citations , October 1982 in “The Journal of Cell Biology”

This study found that the cytokeratin patterns in skin epithelia can distinguish between different types, with basal-cell epitheliomas showing a striking similarity to the pilosebaceous tract.

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community Base for topical finasteride - without min

in Finasteride/Dutasteride 1 upvotes 5 months ago

The conversation is about creating a topical finasteride solution without minoxidil, using an alcohol-based base like ethanol. The discussion includes using finasteride in powder form and mentions adding ingredients like glycerol, salicylic acid, or castor oil.

community Baseline bloodwork before starting Finasteride 1mg EOD – looking for comparison and discussion

2 upvotes 10 months ago

A user shared their baseline bloodwork results before starting Finasteride 1mg every other day, seeking comparison with others who have done similar tests. They are interested in any changes observed after beginning the treatment.

community Baseline vs 6 months of Minoxidil Foam and Finasteride

in Is this regrowth? 803 upvotes 1 year ago

The user is happy with hair regrowth after using Minoxidil foam, Finasteride, and Nizoral shampoo. Some users doubt the authenticity of the results, while others share their own experiences with hair loss treatments.

community Water based carriers and RU-58841

3 upvotes 4 months ago

RU-58841 solutions and their effectiveness for hair loss, with concerns about water-based carriers potentially ruining the compound. Users discuss mixing RU-58841 with alcohol and minoxidil, and experiences vary with some noticing hair loss or shedding.

community Elastin based peptides help reduce wrinkles. Can they help the scalp too?

14 upvotes 5 months ago

Elastin-based peptides may help reduce wrinkles and could potentially benefit the scalp. The conversation suggests using them with hyaluronic acid gel to improve scalp health and reduce hair fall.

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learn Basil Leaf Hairy Root Blend

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learn Exosomes

Do exosome-based treatments require medical supervision or can they be done at home? Exosome-based treatments require medical supervision and should not be done at home.

learn Procyanidin

Are Procyanidin based hair tonics or shampoos effective against androgenic alopecia? Procyanidin-based hair tonics may promote hair growth but lack definitive evidence for AGA.

learn Centella

Could a flaxseed-based hair mask help fight off the DHT effect in your scalp? There is no verifiable evidence that flaxseed lowers DHT or that its lignans penetrate the scalp; a flaxseed gel mask is a cheap emollient that may soothe an irritated scalp, and it is not a treatment for androgenetic alopecia.

learn Sulforaphane

How often should sulforaphane-based products be used for hair loss prevention? No human trial has tested sulforaphane for hair loss prevention, so there is no established usage frequency. Oral supplements are taken daily in research on unrelated conditions and the hair-specific evidence is limited to cell, mouse and isolated-follicle studies, so any schedule is extrapolation rather than a dosing guideline.

learn Tea tree

Can tea tree–based topical products support hair growth indirectly by improving scalp conditions linked to hair loss? Tea tree products may improve scalp health, potentially supporting hair growth indirectly.

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Research

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

research Acidic and basic hair/nail ("hard") keratins: their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins.

research Identification of the cell lineage at the origin of basal cell carcinoma

research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

research Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas.

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community Base for topical finasteride - without min

community Baseline bloodwork before starting Finasteride 1mg EOD – looking for comparison and discussion

community Baseline vs 6 months of Minoxidil Foam and Finasteride

community Water based carriers and RU-58841

community Elastin based peptides help reduce wrinkles. Can they help the scalp too?

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learn Basil Leaf Hairy Root Blend

learn Lipodermal base

learn Exosomes

learn Procyanidin

learn Centella

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learn Tea tree

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Bas Coppelmans

Dr. Atakan Baş, MD

Dr. Bashar Alrahahleh, MD

Dr. Bassam Mohamad Jibaii, MD, ABHRS

Dr. Basim Aydan Droosh, MD

Dr. Bassam Y.A. Ashi

Clinics