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research A Mouse Model for the Basal Transcription/DNA Repair Syndrome Trichothiodystrophy

188 citations , June 1998 in “Molecular cell”

This study found that mimicking the XPD point mutation in mice resulted in trichothiodystrophy-like symptoms, supporting the role of basal transcription and DNA repair defects in the disease.

research A Systematic Review of the Effects of Exercise on Hormones in Women with Polycystic Ovary Syndrome

98 citations , May 2020 in “Journal of Functional Morphology and Kinesiology”

This review finds that vigorous aerobic exercise and resistance training may improve insulin sensitivity and androgen levels in women with PCOS, though more research is needed for definitive conclusions.

research A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice.

89 citations , March 1996 in “Proceedings of the National Academy of Sciences”

This study found that homozygous mutant mice with a hypomorphic CD18 mutation developed a chronic inflammatory skin disease resembling human psoriasis, potentially implicating additional genetic factors in disease susceptibility.

research A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

86 citations , August 2021 in “Polymers”

This review discusses the potential of microneedles to enhance transdermal drug delivery by expanding the range of deliverable drugs, highlighting fabrication methods, material choices, and applications, but notes existing challenges with sustained delivery, cost-effectiveness, and large-scale production.

research A Transition State Analogue of 5′-Methylthioadenosine Phosphorylase Induces Apoptosis in Head and Neck Cancers

75 citations , June 2007 in “Journal of Biological Chemistry”

This study found that the combination of MT-DADMe-ImmA and MTA selectively induced apoptosis in head and neck squamous cell carcinoma cell lines FaDu and Cal27, but not in normal fibroblasts or MTAP-deficient breast cancer cells.

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Community Join

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community Should I avoid a testosterone cycle if I care a lot about keeping my hair?

in Treatment 5 upvotes 4 weeks ago

Avoid testosterone cycles if you care about hair preservation, as they can accelerate hair loss despite using finasteride. Consider alternatives like dutasteride for better protection against hair loss.

community Avodart Dutasteride 0.5mg and Roma Minoxidil 2.5mg

in Finasteride/Dutasteride 6 upvotes 4 months ago

The user is using Avodart Dutasteride 0.5mg and Roma Minoxidil 2.5mg to combat hair loss, with advice suggesting this combination is effective but may take 3-6 months to show results. The user is considering whether to continue the treatment or buzz their hair, seeking reassurance and advice from others.

community Average r/bald user complaining

401 upvotes 9 months ago

Hair loss treatments like Minoxidil, finasteride, and RU58841, focusing on their effectiveness and side effects. It also highlights the disparity in medical research funding between hair loss and conditions like endometriosis.

community The #1 hair transplant clinic red flag (and how to avoid it)

25 upvotes 11 months ago

Avoid clinics that push for more grafts than necessary, as it can lead to unnecessary costs and damage to the donor area. Trust reputable clinics and be cautious of those using celebrity endorsements or offering suspiciously low prices.

community Average guy, average results, 5 years of finasteride

in Progress Pictures 281 upvotes 1 year ago

The user maintained their hair over five years using finasteride and recently started using Rogaine to improve the front. They experienced no side effects and are satisfied with the results, considering the alternative of more significant hair loss.

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Learn

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learn Scalp Micropigmentation

What should I avoid after scalp micropigmentation? Avoid sun exposure, swimming, sweating, and hair products after scalp micropigmentation.
Are there financing options available for scalp micropigmentation? Many providers offer flexible financing options and third-party payment plans for scalp micropigmentation.

learn SCUBE3

Is SCUBE3 available in topical or injectable form, and how is it usually applied in studies? SCUBE3 is not available as a topical or injectable treatment and is not an approved medicine. In the published research it was delivered by microinjecting the recombinant protein into mouse skin and into cultured or grafted human follicles; there are no human clinical trials.

learn Vascular Endothelial Growth Factor

Is Vascular Endothelial Growth Factor (VEGF) available as a topical treatment, or is it only stimulated indirectly? VEGF is not available as a topical treatment for hair loss.

learn Hair Transplant

What financing options are available for hair transplants? Providers typically offer flexible payment plans and third-party financing options for hair transplants.