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This study reports on an ongoing Phase I/IIa clinical trial of ex vivo gene therapy for treating severe Recessive Dystrophic Epidermolysis Bullosa, involving six adult participants with COL7A1 mutations resulting in deficient type VII collagen production.

In this study, inactivating the TAF4 subunit of transcription factor TFIID in mouse epidermis disrupted gene expression linked to skin and hair function, and increased tumor risk.

This study found no evidence of increased keratinocyte proliferation in acne vulgaris, suggesting that other mechanisms may be responsible for hyperkeratinization in acne pathogenesis.

This review examines the use of cultured epithelial autografts (CEA) in burn treatment, highlighting their potential and technical challenges, but reports no new clinical results.

This review highlighted that despite existing treatments, chronic nonhealing leg ulcers remain a significant therapeutic challenge, necessitating the development of new methods that are effective, safe, and affordable for patients.