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research Reactivation of autoimmune hepatitis during budesonide monotherapy, and response to standard treatment

25 citations , October 2010 in “Journal of Hepatology”

This study presented a case where budesonide was insufficient to maintain remission in autoimmune hepatitis, suggesting it may be less effective than prednisolone and associated with notable steroid side effects.

research Cutaneous manifestations of COVID-19 and vaccines for its prevention: a review of the existing literature

April 2026 in “Portuguese Journal of Dermatology and Venereology”

This review summarizes the various skin manifestations linked to COVID-19 infection, vaccination, and personal protective equipment, highlighting their clinical importance and discussing psychological stress and social isolation as additional dermatologic factors.

research Adverse events associated with aromatase inhibitors: an analysis of real-world datasets and drug-gene interaction network

1 citations , November 2024 in “Expert Opinion on Drug Safety”

In this retrospective pharmacovigilance study, researchers analyzed over 7,900 adverse event reports related to aromatase inhibitors, identifying common side effects and toxicological mechanisms to highlight potential safety concerns in treating postmenopausal hormone receptor-positive breast cancer.

research COVID-19 and Autoimmunity in Dermatology: A Moroccan Case Series and Literature Review

April 2024 in “Curēus”

This study reports that COVID-19 can trigger various dermatological autoimmune and autoinflammatory diseases, highlighting the need for clinicians to consider these potential connections during the pandemic.

research Relapsing Course of Sulfasalazine-Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Complicated by Alopecia Universalis and Vitiligo

18 citations , November 2018 in “Annals of the Academy of Medicine Singapore”

Sulfasalazine can cause severe allergic reactions leading to long-term autoimmune issues like hair loss and skin discoloration.

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Learn

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learn Baicapil

Struggling with patchy hair loss like alopecia areata? Baicapil might help by reducing inflammation and reactivating growth. There is no published trial of Baicapil in alopecia areata. The anti-inflammatory and hair-density claims come from the ingredient's manufacturer and from laboratory work on its plant extracts, in people with androgenetic-type hair loss rather than autoimmune patchy hair loss.

learn Cetirizine

Could cetirizine help control autoimmune triggers in alopecia areata? No published trial has tested cetirizine in alopecia areata; one registered trial has not reported results. Small trials in pattern hair loss report modest benefit, so any use for alopecia areata is off-label and unproven.

learn Tofacitinib

What is tofacitinib, and why is it discussed in relation to autoimmune-related hair loss such as alopecia areata? Tofacitinib is a prescription JAK inhibitor approved for rheumatoid arthritis, psoriatic arthritis and ulcerative colitis — not for alopecia areata. It is discussed for hair loss because a 2014 case report and a 2016 open-label trial reported regrowth in severe alopecia areata, but that use is off-label, the regrowth relapsed after stopping, and the drug carries an FDA boxed warning.

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Community Join

5 / 217 results

community Which 2026 hair‑loss treatments have the strongest evidence so far? (minoxidil/finasteride vs. clascoterone, PP405, Re:You’s NV‑623/624, AMP‑303, RU58841)

44 upvotes 3 months ago

Minoxidil and finasteride are the only FDA-approved treatments for androgenetic alopecia, while newer treatments like clascoterone, PP405, NV-623/624, AMP-303, and RU58841 are still experimental with varying levels of evidence. Clascoterone shows the most promise due to strong human data, while AMP-303 has notable early human trial results; RU58841 lacks human data and remains experimental.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Am I missing something with pp405?

34 upvotes 1 year ago

PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

community Most promising cures for baldness as of May 2026

70 upvotes 4 months ago

PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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