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GlossaryNude Mice (Athymic Mice)

laboratory mice lacking a thymus, impairing their immune system

Nude mice, also known as athymic mice, are a type of laboratory mouse that lacks a thymus, resulting in an impaired immune system and an inability to produce T cells. This makes them valuable in scientific research, particularly for studying cancer, immunology, and for growing human tissues and tumors, as they do not reject foreign cells.

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research Assessment of Replication Rates of Human Keratinocytes in Engineered Skin Substitutes Grafted to Athymic Mice

12 citations, June 2012 in “Wound Repair and Regeneration”

Regulating keratinocyte growth in engineered skin can improve wound healing.

Study of the Behavior of Lesional and Nonlesional Skin of Canine Recurrent Flank Alopecia Transplanted to Athymic Nude Mice

research Study of the Behavior of Lesional and Nonlesional Skin of Canine Recurrent Flank Alopecia Transplanted to Athymic Nude Mice

2 citations, July 2013 in “Veterinary dermatology”

Dog skin with hair loss, when transplanted to mice, regrew hair, suggesting the hair loss cause is likely body-wide, not skin-specific.

Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells in Athymic Nude Mice

research Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells in Athymic Nude Mice

January 2016

Tissue from dog stem cells helped grow hair in mice.

Hair Morphogenesis In Vitro: Formation of Hair Structures Suitable for Implantation

research Hair Morphogenesis In Vitro: Formation of Hair Structures Suitable for Implantation

43 citations, August 2008 in “Regenerative Medicine”

Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.

Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse

research Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse

72 citations, December 1996 in “Journal of Investigative Dermatology”

Human hair follicles can regenerate after removal, but with low success rate.

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