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GlossaryNude Mice (Athymic Mice)

laboratory mice lacking a thymus, impairing their immune system

Nude mice, also known as athymic mice, are a type of laboratory mouse that lacks a thymus, resulting in an impaired immune system and an inability to produce T cells. This makes them valuable in scientific research, particularly for studying cancer, immunology, and for growing human tissues and tumors, as they do not reject foreign cells.

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Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

66 citations, August 2001 in “Experimental Dermatology”

Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.

research Assessment of Replication Rates of Human Keratinocytes in Engineered Skin Substitutes Grafted to Athymic Mice

12 citations, June 2012 in “Wound Repair and Regeneration”

Regulating keratinocyte growth in engineered skin can improve wound healing.

Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse

research Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse

72 citations, December 1996 in “Journal of Investigative Dermatology”

Human hair follicles can regenerate after removal, but with low success rate.

Study of the Behavior of Lesional and Nonlesional Skin of Canine Recurrent Flank Alopecia Transplanted to Athymic Nude Mice

research Study of the Behavior of Lesional and Nonlesional Skin of Canine Recurrent Flank Alopecia Transplanted to Athymic Nude Mice

2 citations, July 2013 in “Veterinary dermatology”

Dog skin with hair loss, when transplanted to mice, regrew hair, suggesting the hair loss cause is likely body-wide, not skin-specific.

Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells in Athymic Nude Mice

research Hair Growth Promoting Effect of Dermal Papilla-Like Tissues from Canine Adipose-Derived Mesenchymal Stem Cells in Athymic Nude Mice

January 2016

Tissue from dog stem cells helped grow hair in mice.

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