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research The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men

8 citations , March 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

In this study of healthy men, low levels of testosterone and dihydrotestosterone were associated with higher body mass index, fat content, and insulin resistance, but their effects on lipid and glucose metabolism were similar in quality.

research The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways

21 citations , April 2011 in “Physiological Research”

In this review, the role of DHT in male-type obesity and metabolic diseases is discussed, with increased levels potentially exacerbating cardiovascular disease risk; the paper reports no new results.

research Cellular actions of testosterone in vascular cells: Mechanism independent of aromatization to estradiol

55 citations , June 2012 in “Steroids”

This study found that testosterone modulates vascular cell behavior through direct actions that do not rely on its conversion to estradiol.

research Early breast development in girls after prenatal exposure to non‐persistent pesticides

54 citations , March 2012 in “International Journal of Andrology”

This study found that prenatal exposure to certain pesticides may lead to earlier breast development in girls, potentially associated with higher androgen levels.

research Testosterone: The Male Sex Hormone

May 2023 in “IntechOpen eBooks”

This review outlines the role of testosterone in male sexual development and its therapeutic use for male hypogonadism, covering its biosynthesis, secretion, metabolism, and various biological actions, but does not report specific study results.

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community Aromatise inhibitor for finasteride-estrogen side effects?

5 upvotes 4 years ago

A user experienced mild side effects from 0.5mg finasteride daily, including increased estradiol and minor gynecomastia. They are considering taking a low dose of exemestane to reduce estrogen levels.

community What happens if you combine dutasteride and a aromataze inhibitor?

4 upvotes 7 years ago

Combining dutasteride and an aromatase inhibitor may increase testosterone levels significantly, potentially enhancing athletic performance but also posing health risks like elevated blood pressure and worsened cholesterol. The user is experimenting with dutasteride, anastrozole, minoxidil, and ketoconazole shampoo to manage hair loss and estradiol levels, while monitoring side effects and hormone levels.

community My Estradiol Level on Finasteride

18 upvotes 1 year ago

Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.

community Mechanism of action of alfatradiol (17 alpha estradiol)

5 upvotes 2 years ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community What can be the real reason of Finasteride SE ?

18 upvotes 1 year ago

Finasteride can cause side effects like erectile dysfunction and decreased libido, possibly due to increased estradiol from testosterone aromatization, especially in those with higher body fat. Side effects vary widely and may also be influenced by genetic factors or neurosteroid inhibition.

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