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The Differences Between Aromatizable And Non-Aromatizable Androgens In Relation To Body Composition And Metabolic Syndrome Risk Factors In Men

research The differences between aromatizable and non-aromatizable androgens in relation to body composition and metabolic syndrome risk factors in men

8 citations , March 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

In this study of healthy men, low levels of testosterone and dihydrotestosterone were associated with higher body mass index, fat content, and insulin resistance, but their effects on lipid and glucose metabolism were similar in quality.

research The Role of Non-Aromatizable Testosterone Metabolite in Metabolic Pathways

21 citations , April 2011 in “Physiological Research”

In this review, the role of DHT in male-type obesity and metabolic diseases is discussed, with increased levels potentially exacerbating cardiovascular disease risk; the paper reports no new results.

research Emerging medication for the treatment of male hypogonadism

77 citations , May 2012 in “Expert Opinion on Emerging Drugs”

New treatments for male hypogonadism are effective and should be personalized.

research Dihydrotestosterone, and Not Testosterone, Enhances the LPS-Induced Inflammatory Cytokine Gene Expression in Human Adipocytes

7 citations , April 2023 in “Biomedicines”

This study found that sex hormones, specifically non-aromatizable androgens like DHT and A/T, significantly increase inflammatory cytokine expression in human adipocytes when stimulated by LPS.

Novel Progestogenic Androgens for Male Contraception: Design, Synthesis, and Activity of C7 Alpha-Substituted Testosterone

research Novel progestogenic androgens for male contraception: design, synthesis, and activity of C7 α-substituted testosterone

September 2023 in “Biology of reproduction”

This study suggests that the testosterone analogs 7α-Methyltestosterone and 7α-Ethyltestosterone may offer promising androgenic, progestogenic, and anabolic properties for development as male contraceptives.

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community What are some topical anti androgens(not dht).

3 upvotes 3 months ago

The conversation is about exploring topical anti-androgens for hair loss, specifically mentioning Bicalutamide and the unpleasant smell of Spironolactone. RU58841 is unavailable, and Breezula is suggested as an alternative.

community For those that have used anti androgens what is your experience?

19 upvotes 2 years ago

People discussed their experiences with anti-androgens for hair loss, mentioning side effects like chest pains with RU58841 and skepticism due to lack of safety data, while considering Fluridil as a potential addition to treatment. Some users expressed reluctance to use these chemicals.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Androgen degraders for hair loss

61 upvotes 2 years ago

The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

community What's the best/"safest" topical anti androgen on the market currently?

1 upvotes 11 months ago

The user experienced decreased libido with saw palmetto and is now considering topical anti-androgens like RU58841, pyrilutamide, and topical dutasteride for hair loss. Minoxidil is also mentioned as a potential addition, but the user is cautious about side effects and availability of treatments.

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Learn

5 / 801 results

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn dehydroepiandrosterone

learn Lavender

plant and natural oil with antimicrobial and some anti-androgenic effects

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