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GlossaryBMAL1 (ARNTL)

regulates circadian rhythms and influences biological processes like sleep

BMAL1, also known as Brain and Muscle ARNT-Like 1, is a crucial protein that plays a significant role in regulating the body's circadian rhythms, which are the natural cycles of physical, mental, and behavioral changes that follow a 24-hour cycle. It forms a complex with another protein called CLOCK, and together they help control the expression of genes that influence various biological processes, including sleep-wake cycles, metabolism, and even hair growth.

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research Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles

27 citations, November 2013 in “Journal of Dermatological Science”

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

research Investigation of a Non-Invasive Method of Assessing the Equine Circadian Clock Using Hair Follicle Cells

15 citations, October 2012 in “Journal of circadian rhythms”

RNA from horse hair follicles can track circadian rhythms non-invasively.

research The Circadian Molecular Clock Creates Epidermal Stem Cell Heterogeneity

293 citations, November 2011 in “Nature”

The circadian clock affects skin stem cell behavior, impacting aging and cancer risk.

research The Circadian Clock in Skin

127 citations, January 2015 in “Journal of Biological Rhythms”

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

research Circadian Clock-Mediated Control of Stem Cell Division and Differentiation: Beyond Night and Day

91 citations, August 2014 in “Development”

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

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community How is it that golden era bodybuilders kept their hair while blasting gear while in the modern era most are bald? I’m convinced there’s something in our food and water causing MPB to speed up

in Satire 723 upvotes 1 year ago

The conversation is about the difference in hair loss between bodybuilders in the "Golden Era" and modern bodybuilders. Some users speculate that factors such as the types and doses of steroids used, genetics, diet, microplastics, and overall health may contribute to hair loss. Hair loss prevention medication and transplants are mentioned as potential treatments.

community Testosterone and DHT levels through the roof yet has better hair than the majority of guys who are “healthy” genetics are everything

in Satire 554 upvotes 1 year ago

The conclusion of this conversation about hair loss is that genetics play a significant role in determining hair loss, and specific treatments like finasteride may not be effective against certain compounds like masteron and trenbolone.

community Thoughts about topical minox costco Kirkland 5%- 6 month supply

in Chat 1 year ago

Using topical Minoxidil (Kirkland 5%) to treat thinning hair, with some users reporting positive results and others not seeing any effect. Other treatments mentioned include finasteride and adapalene gel.

community Help interpreting pre-fin bloodwork

in Finasteride/Dutasteride 13 upvotes 3 years ago

A 20-year-old male is unsure how to interpret his bloodwork results and whether he should take finasteride for hair loss. His bloodwork shows borderline high levels of albumin and testosterone, and high progesterone, but normal levels of other hormones.

community No motivation to workout because I’ll be bald no matter what

in Chat 78 upvotes 1 month ago

The conversation is about hair loss affecting motivation to work out. The original poster is using dutasteride and minoxidil and is considering a hair transplant.

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