research Non-competitive androgen receptor inhibition in vitro and in vivo
Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.
Search
forResearch
5 / 1000+ results research Skeletal Site-Dependent Expression of the Androgen Receptor in Human Osteoblastic Cell Populations
This study concluded that higher androgen levels in males and specific skeletal sites may contribute to differences in skeletal morphology, with glucocorticoids, E2, and D3 enhancing androgen receptor expression and mitogenic action in human osteoblastic cells.
research Molecular mechanisms of androgen receptor functions
This thesis reviews the molecular mechanisms of androgen receptor functions, including receptor structure and interaction with other proteins, and reports no new experimental findings.
research Androgen receptor-mediated gene activation in prostate cancer cells
This study provides insight into AR-mediated gene activation and the molecular mechanisms of prostate cancer progression and drug resistance, identifying potential avenues for developing new therapies.
research Androgen Regulation of the Human Hair Follicle: The Type I Hair Keratin hHa7 Is a Direct Target Gene in Trichocytes
This study found that the hHa7 gene in hair follicle trichocytes is the first identified to have its expression directly regulated by androgens, suggesting it as a marker for androgen action on hair follicles.
Community Join
5 / 447 resultscommunity Minoxidil is a 5ar inhibitor according to research
Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.
community Can ashwagandha cause hair loss?
Ashwagandha is generally considered safe for hair while on Dutasteride, as its effects on testosterone are minimal and it may reduce anxiety. Some users report positive effects on hair thickness and anxiety reduction when using ashwagandha alongside finasteride.
community Sugar and Hair loss connections
High sugar diets may worsen hair loss by increasing 5α-reductase activity and androgen levels, especially in women with PCOS. A low sugar diet might reduce scalp DHT levels, similar to finasteride, but genetics also significantly influence hair loss.
community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence
Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.
community Why does the same hormone grow your beard and destroy your hairline?
DHT promotes beard growth but causes scalp hair loss due to inflammation and fibrosis. Treatments like finasteride and minoxidil help with hormonal signals and blood flow but don't address underlying inflammation.
Clinics
2 / 3 resultsExperts
1 / 4 results
Learn
— no results