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GlossaryActivator Protein 1 (AP1)

transcription factor regulating gene expression and cellular processes

Activator Protein 1 (AP-1) is a transcription factor, which means it helps control the expression of certain genes. It is a complex of proteins that binds to specific DNA sequences, thereby regulating processes like cell growth, differentiation, and apoptosis. In the context of hair biology, AP-1 can influence the growth cycle of hair follicles and may play a role in conditions like alopecia.

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Piezo1-Mediated Calcium Signaling Reinforces Mechanical Properties Of Hair Follicle Stem Cells To Promote Quiescence

research Piezo1-Mediated Calcium Signaling Reinforces Mechanical Properties Of Hair Follicle Stem Cells To Promote Quiescence

May 2025 in “Science Advances”

PIEZO1 helps keep hair follicle stem cells inactive, affecting hair growth.

Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

17 citations , February 2015 in “Cell Death and Disease”

Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.

research Identification of Compound Heterozygous Mutations in AP1B1 Leading to the Newly Described Recessive Keratitis–Ichthyosis–Deafness (KIDAR) Syndrome

11 citations , January 2021 in “British Journal of Dermatology”

Mutations in the AP1B1 gene cause a new syndrome with skin, hearing, and developmental issues.

research Lipid-Based Liquid Crystals as Drug Delivery Vehicles for Antimicrobial Peptides

5 citations , January 2017 in “Chalmers Publication Library (Chalmers University of Technology)”

Cubosomes enhance antimicrobial peptide stability and effectiveness.

research The Study of miRNA-211 Affects Melanogenesis Progress in Cashmere Goats via Suppressing AP1S2

February 2025 in “Archives animal breeding/Archiv für Tierzucht”

miRNA-211 reduces melanin in Cashmere goats by suppressing AP1S2.

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