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GlossaryActivator Protein 1 (AP1)

transcription factor regulating gene expression and cellular processes

Activator Protein 1 (AP-1) is a transcription factor, which means it helps control the expression of certain genes. It is a complex of proteins that binds to specific DNA sequences, thereby regulating processes like cell growth, differentiation, and apoptosis. In the context of hair biology, AP-1 can influence the growth cycle of hair follicles and may play a role in conditions like alopecia.

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Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

research Structural and Biochemical Changes Underlying a Keratoderma-Like Phenotype in Mice Lacking Suprabasal AP1 Transcription Factor Function

17 citations, February 2015 in “Cell Death and Disease”

Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.

Piezo1-Mediated Calcium Signaling Reinforces Mechanical Properties Of Hair Follicle Stem Cells To Promote Quiescence

research Piezo1-Mediated Calcium Signaling Reinforces Mechanical Properties Of Hair Follicle Stem Cells To Promote Quiescence

May 2025 in “Science Advances”

PIEZO1 helps keep hair follicle stem cells inactive, affecting hair growth.

Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations, November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

Wnt Signaling in Skin Organogenesis

research Wnt Signaling in Skin Organogenesis

72 citations, April 2008 in “Organogenesis”

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

A Preliminary Study of Differentially Expressed Genes in Expanded Skin and Normal Skin: Implications for Adult Skin Regeneration

research A Preliminary Study of Differentially Expressed Genes in Expanded Skin and Normal Skin: Implications for Adult Skin Regeneration

16 citations, January 2011 in “Archives of Dermatological Research”

The study found that expanded skin regenerates similarly to normal skin, with 77 genes playing a role in the process.

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