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      The Pathogenesis of Alopecia Areata in Rodent Models

      research The Pathogenesis of Alopecia Areata in Rodent Models

      23 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”
      Alopecia Areata is an autoimmune disease affecting hair follicles, influenced by genetic and environmental factors, with rodent models being essential for research.

      research Autoimmune Skin Disease Pathogenesis: A Chronological Immune Cascade and Multi-Hit Model

      January 2026 in “Immunity & Inflammation”
      This review explores the pathogenesis of autoimmune skin diseases using vitiligo as a model to establish a chronological framework of disease onset, progression, and recurrence. It introduces a "stochastic multi-hit model" where disease results from cumulative genetic and environmental factors breaching immunological checkpoints. The review details immune processes such as antigen exposure, T cell priming, and the formation of tertiary lymphoid structures. It also discusses inflammation resolution and recurrence driven by adaptive immunity and inflammatory memory. The framework is extended to other autoimmune skin diseases like alopecia areata, pemphigus vulgaris, and psoriasis, highlighting unexplored mechanistic gaps and offering new directions for research and clinical practice.
      Regulatory T Cells in Autoimmune Skin Diseases

      research Regulatory T Cells in Autoimmune Skin Diseases

      24 citations , March 2018 in “Experimental Dermatology”
      Treg dysfunction is linked to various autoimmune skin diseases, and understanding Treg properties is key for new treatments.

    Community Join

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      community Physician here AMA – 30M oral Fin 1-1.25 mg daily

      in Update  47 upvotes 3 years ago
      Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

      community Interpreting pre-finisteride blood panels

      in Chat  2 upvotes 9 months ago
      The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

      community Pre-Finisteride DHT & Hormone Blood Panel

      in Finasteride/Dutasteride  3 upvotes 10 months ago
      The conversation discusses the cost and insurance coverage of a comprehensive hormone and DHT blood panel for hair loss, with a focus on finasteride treatment. The user seeks a cheaper alternative to a $700 panel recommended in a video.