2 citations,
December 2023 in “Mediterranean Journal of Rheumatology” This study compared the clinical features and autoantibody profiles of late onset (≥50 years) and young onset (18-49 years) Systemic Lupus Erythematosus (SLE) in 305 patients. Late onset SLE patients (n=69) had a mean age of 59.42 years and showed higher frequencies of interstitial lung disease (14.5%), pancytopenia (13%), and diffuse alveolar hemorrhage (4.3%). Significant differences between the groups included higher rates of photosensitivity, malar rash, excessive hair loss, Raynaud's phenomenon, lymphadenopathy, nephritis, and specific autoantibodies (anti-dsDNA, anti-nucleosome, anti-Sm, Ribosomes P0) in young onset SLE. The study concludes that late onset SLE has distinct clinical and serological characteristics compared to young onset SLE.
December 2023 in “Curēus” A woman with lupus had rare severe symptoms but improved with treatment.
31 citations,
March 2018 in “Frontiers in Immunology” The document concludes that anti-dsDNA antibodies are not unique to SLE and their use as indicators is doubtful, highlighting the need for better understanding and classification of the disease.
March 2019 in “Journal of medical science and clinical research” Skin problems are common and early signs of Systemic Lupus Erythematosus, and certain immune system markers are important for diagnosis and treatment.
Systemic lupus erythematosus is diagnosed earlier in males than females.