November 2023 in “Journal of Investigative Dermatology” Inhibiting EGFR weakens skin's defense against bacteria.
April 2018 in “Journal of Investigative Dermatology” This study found that in obese mice, local antimicrobial activity is reduced due to a loss of adipogenic stem cells and an increase in mature adipocytes, leading to higher susceptibility to skin infections.
April 2018 in “Journal of Investigative Dermatology” This study found that TGFbeta is a key pathway causing age-related loss of dermal fat's antimicrobial function, suggesting that targeting TGFBR might help restore skin defense against infections in older age.
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January 2021 in “Journal of Biological Chemistry” This review discusses various amino acid-derived plant defensive compounds and highlights their potential as drug leads due to their potent antimicrobial properties, but reports no new experimental results.
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January 2010 in “Acta Chirurgica Latviensis” In this study, researchers found that psoriasis patients with untreated lesions showed increased activation of defensins, matrix metalloproteinases, and neuropeptides, which may be stimulated by specific inflammation pathways.