October 2022 in “Journal of health sciences and medicine” This study concluded that androgenetic alopecia was not a prognostic indicator for COVID-19, but hospitalization frequency increased in older patients with benign prostatic hyperplasia, supporting an androgen-mediated severity hypothesis.
5 citations
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December 2022 in “Viruses” This review highlights recent insights into using antiandrogens as preventive and therapeutic measures against COVID-19, emphasizing their role in blocking viral infection by modulating androgen-mediated host protease TMPRSS2 and cell entry protein ACE2, with varying success in clinical trials.
123 citations
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May 2020 in “Drug Development Research” This article argues that androgen sensitivity could be a key factor in the severity of COVID-19, suggesting that trials with anti-androgen agents may be warranted.
3 citations
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November 2020 in “Journal of The American Academy of Dermatology” This paper discusses the proposal that androgenetic alopecia, as seen in the "Gabrin sign", could indicate higher risk of severe COVID-19 symptoms, but its validity is questioned and further confirmation is needed.
121 citations
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November 2020 in “Endocrine” This review discusses evidence on androgen sensitivity as a potential factor in COVID-19 disease severity, suggesting that androgen receptor interactions could influence virus entry and progression, and reports no new clinical results.
