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research Established risk factors for coronary heart disease are unrelated to androgen-induced baldness in female-to-male transsexuals

57 citations , January 2004 in “Journal of Endocrinology”

This study found no support for the idea that male-pattern baldness in female-to-male transsexuals indicates an increased risk of coronary heart disease through androgenic effects on classic risk factors.

research [Usefulness and limitations of the evaluation of sex-hormone-binding globulin in women with a female pattern of androgen-induced baldness].

September 1989 in “PubMed”

This study found no significant differences in sex-hormone binding globulin and androgen serum levels between women with stage II androgenetic alopecia and controls, suggesting that genetically-determined androgen sensitivity might play a major role in the condition.

Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

research Androgen Receptor–Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

6 citations , January 2022 in “Journal of Investigative Dermatology”

This study found that androgen receptor signaling is linked to blood vessel regression in the dermal papilla of balding scalp, contributing to hair follicle miniaturization in androgenetic alopecia.

research Topical antiandrogens in the treatment of male-pattern baldness

10 citations , October 1988 in “Clinics in dermatology”

This review discusses the potential of antiandrogens for androgen-induced baldness in men and women but reports no new clinical findings, emphasizing the need for further research on long-term risks and efficacy.

research Hormone-induced aberrations in electromagnetic adhesion signaling as a developmental factor of androgenetic alopecia

4 citations , April 2002 in “Medical Hypotheses”

Hormones cause hair loss by affecting cell growth and weakening cell attraction.

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Community Join

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community Beyond Minoxidil & Finasteride: What if the Answer to Male Pattern Baldness is... on Our Faces? (A Naval Officer's Wild Idea & Why It's Not So Crazy)

11 months ago

Exploring the idea of using facial hair properties for scalp regeneration in male pattern baldness, considering the potential of transferring androgen-resistant characteristics from facial hair to the scalp. Challenges include complexity, scalability, aesthetics, and safety, but the concept encourages innovative thinking beyond current treatments like Minoxidil, Finasteride, and hair transplants.

community Breezula phase 3 results said to be released next month

26 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community Most promising cures for baldness as of May 2026

70 upvotes 4 months ago

PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Finally, some real breakthroughs. A comparison of the two leading baldness treatments: PP405 versus ABS-201

106 upvotes 10 months ago

PP405 and ABS-201 are promising treatments for male pattern baldness. PP405 shows rapid hair growth in human trials, while ABS-201 shows significant regrowth in animal studies but is still in early human trials.

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Learn

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learn Overview

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Hair Transplant

What causes male pattern baldness? Male pattern baldness is caused by genetic sensitivity to the hormone DHT.
What is male pattern baldness? Male pattern baldness is a genetic condition causing hair loss in men, starting with a receding hairline.

learn Finasteride

Does hair strand thickness decrease in men with androgenic alopecia? Can finasteride help restore it? Androgenic alopecia thins hair strands by miniaturizing follicles. The pivotal finasteride trials (1,553 men, 1 mg/day, two years) report increased hair counts and improved assessed appearance, but they measured density, not the diameter of individual strands, so the effect on thickness itself is not established.

learn Fluridil

a topical anti-androgen with less systemic involvement

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