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Glossary Androgen-Dependent

biological process influenced by male sex hormones

Androgen-dependent refers to biological processes or conditions that are influenced or regulated by androgens, which are male sex hormones like testosterone. For example, androgen-dependent hair loss, also known as androgenetic alopecia, occurs when hair follicles shrink due to the effects of these hormones, leading to thinning hair or baldness. This term is crucial in understanding conditions that are influenced by hormonal changes, particularly in the context of hair growth and loss.

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Research

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research Age‐dependent regulation by androgens of gene expression in the anterior hypothalamus and stress‐induced release of adrenal hormones in adolescent and adult male rats

10 citations , March 2019 in “Journal of neuroendocrinology”

This study found that developmental changes in testosterone synthesis and gene regulation may explain age differences in corticosterone release in response to stress between adolescent and adult rats.

Effects of In Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in Male Rats

research Effects of in Utero Exposure to Finasteride on Androgen-Dependent Reproductive Development in the Male Rat

118 citations , May 2003 in “Toxicological Sciences”

This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.

research 202 MicroRNAs in the pathogenesis of male pattern baldness

August 2016 in “Journal of Investigative Dermatology”

This study suggests that differential expression of miRNAs in hair follicles from the frontal and occipital scalp may contribute to the androgen-dependent changes seen in male pattern baldness.

research The Biology of Hair Growth

10 citations , January 2009 in “Elsevier eBooks”

This review discusses the structure, functions, and growth cycle of human hair, emphasizing its reduced growth and protective roles, and reports no new research findings.

research Acquired Progressive Kinking of the Hair: A Narrative Review of the Androgen‐Dependent Phenotype

January 2026 in “International Journal of Dermatology”

This review examines the androgen-dependent subtype of acquired progressive kinking of the hair and suggests it may be an early indicator of androgenetic alopecia, emphasizing the importance of distinguishing between subtypes for clinical decisions.

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Community Join

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community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community KX-826 , a small change in the pipeline

in Research/Science 6 upvotes 7 months ago

KX-826 is undergoing trials for hair loss treatment, showing similar effectiveness between 0.5% and 1.0% dosages, with mild side effects compared to finasteride. Users discuss combining KX-826 with other treatments like minoxidil and clascoterone for better results.

community Has anyone powered through the creatine shedding (via increased androgen receptor sensitivity) and stabilized?

9 upvotes 1 year ago

Creatine may cause increased hair shedding due to androgen receptor sensitivity, despite limited evidence. The user is using dutasteride and minoxidil and seeks advice on whether shedding will stabilize, with suggestions including GHK-Cu and RU58841.

community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 1 year ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

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