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research Androgens and the Female Brain: The Relationship between Testosterone Levels, Depression, Anxiety, Cognitive Function, and Emotion Processing in Females with Polycystic Ovarian Syndrome

1 citations , January 2019

In this study, females with PCOS experienced greater depressive symptoms and cognitive impairment linked to high testosterone levels, but anti-androgen treatment significantly improved mood and cognitive function.

research Androgen excess: a hallmark of polycystic ovary syndrome

December 2023 in “Frontiers in endocrinology”

This review explores the role of hyperandrogenism, including adrenal-derived 11-oxygenated androgen, in the development of polycystic ovarian syndrome and discusses potential therapeutic strategies targeting androgen excess, without reporting new clinical results.

research The pressing need for standardization in epidemiologic studies of PCOS across the globe

15 citations , January 2019 in “Gynecological Endocrinology”

This article discusses the need for a globally standardized protocol for epidemiologic studies of polycystic ovary syndrome to improve study comparability and public health policy.

research Symposium Proceedings of the 4th Intercontinental Meeting of Hair Research Societies: “The World of Hair 2004”

November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses the latest findings presented at the 4th Intercontinental Meeting of Hair Research Societies, covering advances in hair follicle biology, genetic bases for hair disorders, and potential new therapeutic approaches, but it reports no original study results.

research In That Issue: Proceedings From the Third Intercontinental Meeting of Hair Research Societies

May 2003 in “Journal of Investigative Dermatology”

This article reviews the progress in hair biology research, including advancements in understanding androgen action, hair follicle stem cells, and autoimmune mechanisms in alopecia, and reports no new clinical results.

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community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community Evaluate your progress with an objective tool

in Progress Pictures 40 upvotes 2 years ago

The post discusses using ImageJ software to objectively track hair regrowth progress. The user is treating Androgen alopecia with dutasteride and minoxidil.

community People who have overcome the Dutasteride shed, could you please share your story ?

in Finasteride/Dutasteride 8 upvotes 1 month ago

People discussed their experiences with hair loss treatments, particularly dutasteride, finasteride, and minoxidil. Some users reported prolonged shedding with dutasteride, while others suggested adding topical anti-androgens like RU58841 to manage shedding.

community Been off Tressless for a few years - what’s the latest on GT20029?

17 upvotes 1 month ago

GT20029 is an experimental topical treatment for male-pattern hair loss, showing promising results in Phase 2 trials and moving towards Phase 3. It aims to degrade androgen receptors in hair follicles, differing from treatments like finasteride and minoxidil.

community End of Hair loss ( AGA ) ? Since they produce it in china probably we don’t need to wait other 10 yrs😁

276 upvotes 6 months ago

GT20029 is a new hair loss treatment in Phase 3 trials in China, using PROTAC technology to target androgen receptors, potentially with fewer side effects than finasteride and minoxidil. VDPHL01, a second-generation minoxidil, is also mentioned as potentially more effective.

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Learn

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learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Spironolactone

Who can safely use spironolactone for hair thinning and androgen-related hair loss? Women with androgen-related hair loss can safely use spironolactone under medical supervision.

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

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