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Use of Androgen Lowering Medications Finasteride and Dutasteride Do Not Substantially Alter Risk of Incident HCV-Related Hepatocellular Carcinoma in Men

research Tu1491 – Use of Androgen Lowering Medications Finasteride and Dutasteride Do Not Substantially Alter Risk of Incident Hcvrelated Hepatcellular Carcinoma in Men

May 2019 in “Gastroenterology”

Androgen lowering medications don't significantly change HCV-related liver cancer risk in men.

research INSULIN-LOWERING MEDICATIONS IN POLYCYSTIC OVARY SYNDROME

39 citations , September 2000 in “Obstetrics and Gynecology Clinics of North America”

This article reviews evidence on hyperinsulinemia and insulin resistance in women with polycystic ovary syndrome and evaluates therapeutic responses to insulin-lowering agents, reporting no new clinical findings.

research Impaired Prolactin-Lowering Effects of Metformin in Women with Polycystic Ovary Syndrome

August 2023 in “Journal of Clinical Medicine”

This study found that metformin's effect on reducing prolactin levels is less pronounced in women with PCOS compared to control subjects, likely due to higher endogenous testosterone levels, despite improvements in insulin sensitivity in both groups after six months of treatment.

research Endocrinology of Transgender Medicine

166 citations , October 2018 in “Endocrine Reviews”

This review discusses the effects of hormonal treatments on the physical and mental health of transgender individuals, reporting significant reductions in mental health issues following treatment, but calls for more research on long-term and nonbinary outcomes.

research Polycystic ovary syndrome and insulin-resistant hyperinsulinemia

60 citations , September 2001 in “Journal of the American Academy of Dermatology”

This review discusses the relationship between insulin regulation and hyperandrogenemia in polycystic ovary syndrome, suggesting potential benefits of insulin-lowering treatments for ovarian function but reporting no definitive results for hair-related symptoms.

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Community Join

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community Cypro to reverse hairloss + Fin?

in Treatment 1 year ago

The conversation discusses using cyproterone temporarily to reverse hair loss, followed by finasteride to maintain regrowth. Concerns about cyproterone's side effects, such as lowering testosterone and potential health risks, are raised, with alternatives like spironolactone suggested for androgen-related issues.

community Insulins impact on androgen levels

16 upvotes 4 years ago

Controlling insulin levels through intermittent fasting and a low glycemic diet may improve hair quality by reducing androgens. It's important to maintain proper nutrition, including electrolytes and protein, during fasting.

community 2 years of Androgen inhibition.

144 upvotes 1 year ago

A 23-year-old has been using finasteride, dutasteride, and spironolactone to combat hair loss and hormonal acne, with mixed results and concerns about side effects. The user is experimenting with spironolactone despite its potential risks, hoping for skin and body hair improvements.

community No fearmongering /just facts on yesterday someone posting on eye issues

in Finasteride/Dutasteride 33 upvotes 1 year ago

Finasteride and dutasteride may not significantly impact meibomian gland function since these glands do not rely on DHT. Some users report dry eyes and other side effects from finasteride, but these may be influenced by other factors or medications.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

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Learn

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learn Overview

learn Follistatin

How does follistatin compare to finasteride or dutasteride for treating androgenic alopecia? Finasteride and dutasteride are prescription drugs with large controlled trials showing they lower DHT and slow androgenic hair loss, at the cost of documented hormonal side effects; follistatin targets a different, regenerative pathway but has only one small phase 1 human trial behind it, so it is experimental with unknown safety rather than a comparable alternative.

learn Bicalutamide

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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