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    GlossaryAndrogen Insensitivity Syndrome

    genetic condition causing resistance to male hormones in XY individuals

    Androgen Insensitivity Syndrome (AIS) is a genetic condition where a person who is genetically male (with one X and one Y chromosome) is resistant to male hormones called androgens. As a result, the person has some or all of the physical traits of a woman, but the genetic makeup of a man. This can lead to a range of physical manifestations, from completely typical female external genitalia to ambiguous genitalia, depending on the degree of insensitivity.

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      learn Fluridil

      a topical anti-androgen with less systemic involvement

      learn Pyrilutamide

      highly targeted anti-androgen that might have minimal systemic effects

      learn Bicalutamide

      a nonsteroidal anti-androgen, most commonly used orally for women

      learn Cyproterone

      a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

      learn Spironolactone

      powerful topical and oral anti-androgen used mostly by women

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      community Fun thought experiment about halting hair loss permamently

      in Research/Science  58 upvotes 6 months ago
      A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.

      community Got my DHT levels checked. 38 year old female. Still losing hair.

      in Female  10 upvotes 6 months ago
      A 38-year-old female is experiencing hair loss despite having almost undetectable DHT levels after using dutasteride. Suggestions include checking for PCOS, thyroid issues, adjusting diet, considering the impact of birth control, and trying treatments like tretinoin, redensyl, retinol, and minoxidil with derma stamping.

      community How does dutasteride regrowth work?

      in Finasteride/Dutasteride  6 upvotes 6 months ago
      A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.