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research Antiandrogens and Androgen Inhibitors

November 2020 in “Elsevier eBooks”

This source outlines various antiandrogen and androgen inhibitor drugs used to treat cutaneous disorders of hyperandrogenism, detailing their mechanisms, uses, dosages, and side effects, with emphasis on spironolactone, finasteride, dutasteride, and oral contraceptives.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that despite the presence of steroidogenesis inhibitors, CRPC tumor cells adapt to continue synthesizing androgens, suggesting a need for more effective androgen axis targeting.

research Steroid inhibitors of androgen-potentiated actions on skin

4 citations , July 1983 in “Journal of steroid biochemistry/Journal of Steroid Biochemistry”

In this study, hirsute women treated with cyproterone acetate and ethinyloestradiol experienced significant reductions in sebum secretion and hair growth after several months.

research Computational Evaluation of Dibenzo Compounds as Potential Dual Inhibitors of Androgen Receptor and 5α-Reductase

January 2022 in “Asian journal of Current Research in Clinical Cancer”

This study reviews the potential of dibenzo derivatives as safer cancer treatments but finds conflicting evidence about their effectiveness, possibly due to structural differences among the compounds, and reports no new results.

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.

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community Recommendation for Topical Androgen Inhibitor While on 0.5mg/Day Dutasteride

in General 72 upvotes 11 months ago

The user is taking dutasteride 0.5mg daily and seeks a topical androgen inhibitor for the scalp. They are looking for recommendations to enhance their hair loss treatment.

community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community Minoxidil is a 5ar inhibitor according to research

150 upvotes 11 months ago

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

community Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy

2 upvotes 1 year ago

Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.

community Breezula Phase 3 Results enough for maintenance?

13 upvotes 4 months ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn Fluridil

How is Fluridil different from other DHT blockers like finasteride? Fluridil is a topical androgen-receptor blocker applied to the scalp, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT throughout the body. Finasteride is FDA-approved and far better studied; Fluridil rests on one 43-man trial and is not licensed as a hair-loss medicine, so its long-term safety and effect size are unknown.

learn RU58841

a potent but unapproved and potentially problematic topical anti-androgen

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

learn Spironolactone

Who can safely use spironolactone for hair thinning and androgen-related hair loss? Women with androgen-related hair loss can safely use spironolactone under medical supervision.

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

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