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5 / 12 resultslearn Cyproterone
a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
learn Finasteride
Frontline, gold standard treatment for combatting androgenic alopecia
learn Pyrilutamide
highly targeted anti-androgen that might have minimal systemic effects
learn Fluridil
a topical anti-androgen with less systemic involvement
Research
5 / 1000+ resultsresearch Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen.
Testosterone helps beard and axillary hair cells grow by releasing growth factors from dermal papilla cells.
research Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen
Testosterone increases hair follicle cell growth when beard or axillary skin cells are present together.
![Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque<sup>1</sup>](/images/research/bfbc2669-6de8-456c-a334-f096d9e84de1/small/12619.jpg)
research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque1
Testosterone can slow down hair growth when combined with certain cells from bald scalps, and this effect can be blocked by an androgen receptor blocker.
research Mechanism of action of androgen in hair follicles
Testosterone affects hair follicles differently across body sites, with beard hair follicles showing more activity of a specific enzyme and presence of androgen receptors compared to scalp hair.
![Pathomechanism of androgenetic alopecia and new treatment](/images/research/fe0ab07a-cead-4a89-add7-ad8ce4ab438e/small/2516.jpg)
research Pathomechanism of androgenetic alopecia and new treatment
Male pattern baldness is caused by certain cells in hair follicles and could potentially be treated by targeting a specific growth factor, TGF-β1.
Community Join
5 / 1000+ resultscommunity After 11 Years On Finasteride, Unfortunately, Hair Is Starting To Thin Again. Does Hair Simply Get More Sensitive To DHT As You Age?
After 11 years on Finasteride, a user's hair is thinning again, suggesting hair may become more sensitive to DHT with age. They plan to introduce Dutasteride once a week, as they cannot tolerate Minoxidil.
community Please explain this Minoxidil phenomena
The post discusses the difference in effects of Minoxidil (Min) on scalp and facial hair. The user questions why Min-induced hair growth on the scalp is temporary, while facial hair growth seems permanent, even after stopping Min. They propose theories, including different Min mechanisms on body and facial hair, the role of DHT, and the possibility of not achieving fully terminal hair. The responses include personal experiences and theories about Min's effects on hair growth.
community Scalp tension and thickness of the galea aponeurotica, inflammation and potential treatment pathways
Scalp tension potentially affecting hair loss, and potential treatments for male pattern baldness such as Minoxidil, Finasteride and RU58841. Evidence from a study was discussed which suggests that the cause of MPB lies within the follicle itself and is not dependent on its surrounding environment.
community I experimented with every medication for hair loss for at least 1 year. my thoughts.
Minoxidil effective for regrowth but causes dryness; finasteride stops hair loss but may affect hormones; dutasteride powerful but reduces libido; RU58841 thickens hair but expensive and risky; dermarolling improves blood flow and results; aminexil overrated and not effective. Dermarolling beneficial with both minoxidil and finasteride.
community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.
A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.