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research Androgen excess: Investigations and management

82 citations , May 2016 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

This article outlines the clinical features, evaluation, and treatment strategies for androgen excess in polycystic ovary syndrome, highlighting important diagnostic and management approaches but reporting no new research results.

research Androgenetic alopecia: An autosomal dominant disorder

80 citations , January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

research Consecuencias civiles en el impago de la primera prima o sucesivas de la póliza de seguro en los juicios penales por accidente de tráfico: ¿tiene cobertura por la aseguradora el conductor?

January 2009 in “La ley penal: revista de derecho penal, procesal y penitenciario”

This review discusses the multifaceted etiology of androgenetic alopecia and reports no new clinical results; the authors emphasize the potential benefits of combining different therapeutic modalities.

research The Effect of Perinatal Blockade of Androgen Receptors on the Expression of Hypothalamic Estrogen Receptor‐a and Sexual Motivation in Male Rats

April 2016 in “The FASEB Journal”

This study found that blocking androgen receptors in male rats during the perinatal period led to permanently increased estrogen and ER-a expression in the hypothalamus, affecting sexual preference in adulthood.

research A new look at an old option in the treatment of early-stage prostate cancer: hormone therapy as an alternative to watchful waiting

5 citations , September 1998 in “Medical hypotheses”

This article discusses the potential of using flutamide and finasteride for complete androgen blockade in early-stage, low-grade prostate cancer and suggests they may improve symptom-free and overall survival compared to observation.

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Learn

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learn Stem Cell Factor

learn Bicalutamide

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss. The published evidence is retrospective case series and one small pilot study, with no randomized trial; it is a prescription drug that requires liver monitoring and is contraindicated in pregnancy.
Why are some women using bicalutamide to fight hormonal hair loss? Bicalutamide blocks androgens, helping women combat hormonal hair loss effectively.

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

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Community Join

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community 2 years of Androgen inhibition.

144 upvotes 1 year ago

A 23-year-old has been using finasteride, dutasteride, and spironolactone to combat hair loss and hormonal acne, with mixed results and concerns about side effects. The user is experimenting with spironolactone despite its potential risks, hoping for skin and body hair improvements.

community CURCUMIN - Effect on Androgens, Testosterone, DHT - A Brief Review of the Literature

2 upvotes 5 years ago

community If DHT is the cause of hair loss why do so many still lose hair on dutasteride?

in Finasteride/Dutasteride 9 upvotes 3 weeks ago

Hair loss can persist despite using treatments like finasteride, dutasteride, and minoxidil due to factors like genetic sensitivity, incomplete DHT blockage, and other hormonal influences. Individual responses vary, and some may require a combination of treatments to stabilize hair loss.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

133 upvotes 2 years ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community There’s nothing better on the horizon [RANT]

22 upvotes 1 month ago

There is skepticism about new hair loss treatments, with the belief that current options like minoxidil, finasteride, and hair transplants are the best available. Concerns are raised about the systemic side effects of androgen-related treatments, even those marketed as topical, and doubts about the effectiveness of emerging treatments like clascoterone.

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