October 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This study suggests that PGD2 may increase testosterone production in keratinocytes through oxidative stress pathways, with n-acetyl-cysteine blocking this effect.
July 2026 in “Current Medical Issues” In this study, using EMLA cream did not adequately control pain during and after scalp PRP injections for androgenetic alopecia, with anxiety and younger age linked to higher pain levels.
May 2024 in “Open Access Journal of Disease and Global Health” This qualitative study reported that platelet-rich plasma treatments improved patient satisfaction and quality of life by enhancing facial texture and hair quality, supporting PRP as a viable option for conditions like alopecia and skin rejuvenation.
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July 2020 in “Journal of Cosmetic Dermatology” This study found that using a vibration anesthetic device during scalp mesotherapy significantly reduced pain in patients with androgenetic alopecia and alopecia areata compared to the non-vibration side.
This study found that the Leni wand device, which combines cold and vibration, was more effective at reducing pain from local anesthesia injections during hair transplant surgery than a device using only vibration, although results were obtained solely from a male participant group.