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Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

research Synthesis and 5α-Reductase Inhibitory Activity of 8-Substituted Benzo[ƒ]Quinolinones Derived from Palladium Mediated Coupling Reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

research Design, Synthesis, and Structure-Activity Relationship Studies on Steroidal Aromatase and 5α-Reductase Inhibitors as Anti-Tumor Agents

December 2013 in “Estudo Geral (Universidade de Coimbra)”

Modified steroidal inhibitors showed promise in treating hormone-dependent cancers.

research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry

71 citations , January 2014 in “Journal of Proteome Research”

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

research Design, Synthesis and Anxiolytic Activity Evaluation of N-Acyltryptophanyl-Containing Dipeptides, Potential TSPO Ligands

16 citations , November 2018 in “Medicinal Chemistry”

The compound GD-23 may reduce anxiety like diazepam by targeting the TSPO receptor.

research A Report on the Dissolved Bioactive Compounds of Medicinal Values in the High Altitude Hot Springs of Ladakh

July 2025

Ladakh hotsprings contain compounds with potential medicinal benefits for various health conditions.

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community Don't use PP405 from everychem. it is likely fake.

in Research/Science 66 upvotes 4 months ago

PP405 from Everychem is likely fake and potentially harmful, with concerns about its stability and the risk of using the wrong MPC inhibitor, which could damage hair follicles. The real PP405 was studied under strict conditions, and DIY attempts are discouraged due to unknown formulation and quality control.

community hmi115 is coming. Prepare yourselves for what's coming

in Technology 109 upvotes 2 years ago

The conversation discusses HMI-115, a potential cure for hair loss. Users share mixed opinions, with some expressing skepticism and others sharing anecdotal evidence of its effectiveness, including photos of significant hair regrowth from a trial participant.

community Is this subtle improvement or are my eyes playing tricks on me?

in Progress Pictures 25 upvotes 2 weeks ago

The user is experiencing noticeable hair improvement after 4.5 months of using a treatment regimen including minoxidil, finasteride, biotin, Nioxin shampoo, microneedling, topical NANoxidil, and copper peptides. Feedback from others is positive, encouraging the user to continue the treatment for at least a year or more.

community I hope ET-02 or PP405 will be released in the next 4-5 years

in Product 15 upvotes 5 months ago

PP405 is a potential hair loss treatment that may work by blocking signals that cause hair cells to stop growing, requiring daily application for effectiveness. It could serve as an alternative to minoxidil and finasteride, but it is not yet available on the market and may take several years to be released.

community M19 shed after 1yr on dutasteride

in Finasteride/Dutasteride 23 upvotes 1 year ago

A 19-year-old male experienced hair shedding after one year on dutasteride and is considering adding topical minoxidil despite scalp itching. Users suggest continuing dutasteride, maintaining a consistent hair routine, and possibly increasing minoxidil dosage.

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