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Glossary Adult Stem Cells

undifferentiated cells in adults that regenerate specific tissues

Adult stem cells, also known as somatic stem cells, are undifferentiated cells found throughout the body after development. They have the ability to self-renew and differentiate into various specialized cell types of the tissue or organ they reside in, playing a crucial role in tissue repair and regeneration. Unlike embryonic stem cells, adult stem cells are limited in their differentiation potential but are less likely to cause ethical concerns or immune rejection when used in therapies.

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research Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity

200 citations , March 2023 in “Nature Reviews Molecular Cell Biology”

This review discusses the role and regulation of quiescent adult stem cells in tissue maintenance and repair, focusing on molecular mechanisms and their implications for regenerative medicine, but reports no new clinical results.

research Switching roles: the functional plasticity of adult tissue stem cells

87 citations , March 2015 in “The EMBO Journal”

This review discusses the plasticity of stem cell populations and their ability to switch between functions for tissue homeostasis and regeneration, emphasizing environmental and hormonal influences, and reports no new results.

research Linking chromatin dynamics, cell fate plasticity, and tissue homeostasis in adult mouse hair follicle stem cells

3 citations , July 2017 in “Endogenous locus-driven H-Ras G12V expression induces senescence-like phenotype in primary fibroblasts of the Costello syndrome mouse model”

This study found that mouse hair follicle stem cells in a quiescent state exhibit greater chromatin dynamics and de-differentiation potential, suggesting higher cell fate plasticity compared to their proliferative or differentiated counterparts.

research POLYCOMB REPRESSIVE COMPLEX 1 IS REQUIRED TO MAINTAIN STEM CELL IDENTITY AND TO PRESERVE ADULT TISSUE HOMEOSTASIS.

January 2020 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)”

This study found that Polycomb Repressive Complex 1 is crucial for maintaining stem cell identity across different lineages, but its loss results in varied transcriptional outcomes depending on the tissue context.

research Dental tissues as adult stem cell source

2 citations , January 2013 in “Journal of the Korean Association of Oral and Maxillofacial Surgeons”

This review discusses the potential of dental tissues as an alternative source of adult stem cells for regenerative medicine but reports no new experimental results, emphasizing the need for effective preservation methods.

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community The end of balding: We may have just found the secret to hair regrowth

in Technology 680 upvotes 1 year ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.

community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

44 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community Update and new paper from Dr tsuji

26 upvotes 7 years ago

Hair follicle regenerative therapy is being developed, with clinical trials planned in Japan, potentially allowing for hair cloning and eliminating the need for treatments like finasteride. If successful, the treatment could be available in Japan by 2025, but widespread access and affordability may take longer.

community Am I missing something with pp405?

34 upvotes 1 year ago

PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

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