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research A Machine Learning and Network Framework to Discover New Indications for Small Molecules

August 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

The model successfully predicted new uses for existing drugs, like using certain hormonal and heart medications for respiratory and Parkinson's diseases, and a cancer drug for diabetes.

research A Machine Learning and Network Framework to Discover New Indications for Small Molecules

8 citations , August 2020 in “PLOS Computational Biology”

A machine learning model called CATNIP can predict new uses for existing drugs, like using antidepressants for Parkinson's disease and a thyroid cancer drug for diabetes.

research Pharmacophore Modeling and Three Dimensional Database Searching for Drug Design Using Catalyst: Recent Advances

153 citations , November 2004 in “Current Medicinal Chemistry”

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

research The Cutaneous Serotoninergic/Melatoninergic System: Securing a Place Under the Sun

349 citations , January 2005 in “The FASEB journal”

Human skin can make serotonin and melatonin, which help protect and maintain it.

research Melatonin

220 citations , August 1988 in “Clinical endocrinology”

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

View more "adrenergic uptake inhibitors" in research →

Community Join

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community After quitting min and fin I asked AI on how fix the mess I am in and it says:

in Technology 2 months ago

Prolonged use of topical minoxidil and finasteride can lead to neuroendocrine and autonomic dysfunction, causing severe sensitivity and side effects. Recovery involves avoiding these treatments, supporting neurosteroid recovery, calming the sympathetic system, and rebuilding scalp health naturally.

community (comment) providing facts on people talking nonsense about minoxidil and BP-medicaton in general

in Research/Science 18 upvotes 1 year ago

Minoxidil is used for hair loss and sometimes for high blood pressure, but it's outdated for the latter. For high blood pressure, it's combined with a beta blocker and diuretic to manage side effects.

community 5% Minoxidil after 4 months - started with twice a day but went down to once because I kept forgetting in the morning. Really happy with how it is going!

in Progress Pictures 438 upvotes 2 years ago

The conclusion of the conversation is that the user started using 5% Minoxidil for hair loss and is happy with the progress. They also mentioned being trans and coming off testosterone, which they believe will help prevent further hair loss. Some users suggested using finasteride as well.

community The truth about Dutasteride (w/ sources)

in Finasteride/Dutasteride 52 upvotes 2 years ago

The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.

community 3 months of 1 mg finasteride and 5 mg minoxidil (oral)

in Progress Pictures 3 years ago

A user's progress with hair regrowth after 3 months of using 1 mg finasteride and 5 mg minoxidil orally, despite some skepticism from other users. The user reports having low blood pressure and feeling fatigued as side effects, but others suggest switching to topical minoxidil for better results with less risk.