January 2011 in “Padua Research Archive (University of Padua)” This study suggests that human skin locally synthesizes active sex steroid hormones, impacting inflammation, cell behavior, and wound healing, with potential implications for therapies in aging and impaired wound recovery.
151 citations
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December 2004 in “Annals of the New York Academy of Sciences” This review discusses nonclassical 21-hydroxylase deficiency as the most common autosomal recessive disorder in humans and highlights the effectiveness of glucocorticoid treatment in reversing related symptoms.
57 citations
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April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that despite the presence of steroidogenesis inhibitors, CRPC tumor cells adapt to continue synthesizing androgens, suggesting a need for more effective androgen axis targeting.
May 2021 in “Journal of the Endocrine Society” This case study reports a patient with ACTH-driven cortisol secretion 14 years after adrenalectomy, suggesting possible residual adrenal tissue or extra-adrenal steroid synthesis, challenging the need for lifelong steroid replacement.
11 citations
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May 2024 in “Reproductive Biology and Endocrinology” In this study, researchers found that human ovaries at different life stages biosynthesize both canonical and non-canonical steroid hormones, with fetal ovaries showing higher enzyme activity related to estradiol and testosterone conversion compared to adult tissues.