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research Serum Androgens in Normal Prepubertal and Pubertal Children and in Children with Precocious Adrenarche

192 citations , January 1976 in “The Journal of Clinical Endocrinology & Metabolism”

This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.

Nonclassic Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency: Pathophysiology, Diagnosis, and Treatment

research Nonclassic Congenital Adrenal Hyperplasia

49 citations , January 2010 in “International Journal of Pediatric Endocrinology”

This review covers the pathophysiology, diagnosis, and treatment of nonclassic congenital adrenal hyperplasia due to P450c21, but it reports no new clinical results.

research The Rise in Adrenal Androgen Biosynthesis: Adrenarche

173 citations , November 2004 in “Seminars in Reproductive Medicine”

This review discusses the physiological process of adrenarche, its impact on behavior and skeletal maturation, and its variability across sex and race, but reports no new clinical results.

research Studies on changes in the concentration of serum adrenal androgens in pubertal twins

30 citations , March 1980 in “European Journal of Endocrinology”

This study suggests that genetic factors significantly influence adrenal androgen levels and the progression of puberty, with adrenal cortex maturation appearing independent of the hypothalamic-pituitary-gonadal axis.

Premature Adrenarche: Early Maturation of Adrenal Glands in Children

research Premature Adrenarche

31 citations , January 2018 in “Pediatric annals”

This article reviews the characteristics, diagnosis, and management of premature adrenarche and suggests it may predict future ovarian hyperandrogenism in some adolescents; no new clinical results are reported.

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community DHT and 5AR respect post, it's importance within the brain

in Research/Science 111 upvotes 2 years ago

The conversation discusses whether to use finasteride for hair loss, considering its role in inhibiting DHT and 5AR, which can affect brain function and mood. Some users report anxiety and depression from finasteride, while others do not experience these side effects and emphasize the importance of DHT for brain and prostate health.

community Thoughts about ORAL ketoconazole? (pills)

8 months ago

Oral ketoconazole is discussed as a potential hair loss treatment, but it poses significant health risks like liver damage and adrenal insufficiency. Users suggest safer alternatives like topical anti-androgens or spironolactone, emphasizing the importance of consulting a specialist.

community Bicalutamide effect on androgens?

5 upvotes 5 years ago

Bicalutamide blocks androgen receptors, preventing testosterone and DHT from binding, which can help with hair loss but may cause feminization. It is not recommended for those who do not want feminization effects.

community If we lose hair because of our sensitivity to DHT, then why are we trying to reduce DHT when our sensitive androgen receptors are the culprit?

13 upvotes 4 years ago

The conversation discusses the effectiveness of reducing DHT for hair loss treatment and explores alternative approaches like reducing androgen receptor sensitivity. Specific treatments mentioned include finasteride, dutasteride, pyrilutamide (KX-826), GT20029, and RU58841.

community here is why isotretinoin might cause hair loss and maybe why dupa happens.

in Research/Science 7 upvotes 3 years ago

Isotretinoin may cause hair loss by increasing DHT through a precursor androgen, DHEAS. Treatments like topical antiandrogens (RU58841, pyrilutamide) and drugs increasing PPAR-y expression (pioglitazone) might prevent this hair loss.

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learn dehydroepiandrosterone

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