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research Decision Letter: Human Biallelic MFN2 Mutations Induce Mitochondrial Dysfunction, Upper Body Adipose Hyperplasia, and Suppression of Leptin Expression

January 2017

MFN2 mutations cause mitochondrial problems, unusual fat distribution, and low leptin despite high body fat.

research Literature Review of Cosmetic Procedures in Men: Approaches and Techniques Are Gender Specific

20 citations , December 2016 in “American Journal of Clinical Dermatology”

Men prefer less invasive cosmetic procedures and need different treatment approaches than women.

research Hyperplasia of the Subcutaneous Adipose Tissue Is the Primary Histopathologic Abnormality in Lipedematous Scalp

32 citations , June 2003 in “The American Journal of Dermatopathology”

Lipedematous scalp is mainly caused by an increase in fat tissue under the skin and is different from lipedematous alopecia.

research Dermal White Adipose Tissue: A Newly Recognized Layer of Skin Innate Defense

49 citations , March 2019 in “Journal of Investigative Dermatology”

Skin fat plays a key role in immune defense and healing beyond just storing energy.

research A Comprehensive Review on Metabolic Syndrome

1341 citations , January 2014 in “Cardiology Research and Practice”

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

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community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 96 upvotes 5 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community New Hair Loss Treatment: Adipose Derived Secretomes

in Research/Science 17 upvotes 6 months ago

Adipose-derived stem cell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.

community Increased adipose tissue (being overweight) in males may increase likelyhood of finasterde side effects

in Research/Science 27 upvotes 1 year ago

Being overweight may increase finasteride side effects due to higher aromatase activity converting testosterone to estradiol. Maintaining a healthy weight could reduce these side effects.

community The Big Fat Layer II

in Research/Science 25 upvotes 4 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

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