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research Exploring Acne Treatments: From Pathophysiological Mechanisms to Emerging Therapies

68 citations , May 2024 in “International Journal of Molecular Sciences”

This review of acne management strategies highlights current treatments, such as topical and systemic therapies, procedural methods, and dietary changes, while also discussing emerging options like biologics and probiotics as potential future treatments, emphasizing personalized care due to acne's complex nature.

research Pathways to inflammation: acne pathophysiology

68 citations , May 2011 in “European Journal of Dermatology”

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

research The pathophysiology of polycystic ovary syndrome

249 citations , November 2003 in “Clinical endocrinology”

This review discusses the complex etiology of polycystic ovary syndrome (PCOS), highlighting its association with insulin resistance and hyperandrogenism, but reports no clinical findings; the authors suggest further investigation of the pathophysiological mechanisms.

research Acne scars: Classification and treatment

1 citations , December 2011 in “Journal of The American Academy of Dermatology”

This book review examines various classification and treatment methods for acne scars, emphasizing the complexity and need for multiple therapeutic approaches, but reports no new clinical results.

research Polymorphisms in Genes Involved in Steroidogenesis in the Development of Severe Acne

September 2021 in “International Journal of Biomedicine”

This study found that SNPs in the MVK, ARPC1B, and CA2 genes may indicate a genetic predisposition for severe acne related to steroidogenesis.

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community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 44 upvotes 2 years ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community How is this even possible that there is no cure till now

in Technology 155 upvotes 5 months ago

There is no permanent cure for hair loss; treatments like finasteride, minoxidil, and hair transplants require ongoing use and are not universally effective. Genetic complexity and financial incentives for ongoing treatments hinder the development of a definitive cure.

community dut doomers - any photo evidence of people regrowing AFTER going back to fin?

in Finasteride/Dutasteride 23 upvotes 10 months ago

Some users experience worsening hair loss with dutasteride and improvement after switching back to finasteride, while others find better results with dutasteride. The effectiveness of treatments like finasteride, dutasteride, minoxidil, and RU58841 varies, requiring individuals to try different combinations or dosages to find what works best.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

124 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

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learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Overview

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