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research Alopecia Areata: Updates from the Mouse Perspective

8 citations , December 2013 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This review discusses recent advancements made in using mouse models to investigate the genetic complexity and pathogenesis of alopecia areata, emphasizing potential new treatment targets, but it reports no new findings.

research Distinguishing Mouse Strains by Proteomic Analysis of Pelage Hair

34 citations , March 2009 in “Journal of Investigative Dermatology”

Proteomic analysis can identify genetic differences in mouse hair, helping understand hair defects and variations.

research Mutations in Sterol O-Acyltransferase 1 (Soat1) Result in Hair Interior Defects in AKR/J Mice

23 citations , June 2010 in “Journal of Investigative Dermatology”

This study found that the hair interior defect in AKR/J mice is linked to a mutation in the Soat1 gene, which disrupts SOAT1 protein expression and affects lipid metabolism critical for normal hair formation.

research Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains

6 citations , October 2018 in “PLoS ONE”

This study found that chronic stress may inhibit hair follicle growth and melanogenesis in mice through modulation of the central HPA axis, with C57BL/6 mice appearing most sensitive to these effects.

research Immunoperoxidase anti-keratin staining of epidermal and pilar cysts

10 citations , July 1984 in “British Journal of Dermatology”

In this study, the staining properties of two types of cysts, epidermal and pilar, were found to differ, supporting their origins from the epidermis and the trichilemmal hair follicle layer, respectively.

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5 / 197 results

community (Topical) Quercetin might be a good add on to the hair loss stack

8 upvotes 3 years ago

Quercetin might help with hair loss by inhibiting HSP-70, which increases androgen receptors. Concerns include its staining properties and unclear topical absorption.

community Approximation of Scalp DHT Suppression Between 0.05 mg to 2.5 mg

in Research/Science 63 upvotes 2 years ago

The conversation discusses the effectiveness of various doses of Dutasteride in reducing scalp DHT and its impact on hair count. Users shared personal experiences with hair loss treatments, including Dutasteride, Finasteride, and Minoxidil, with one reporting significant hair loss reduction using a combination of oral Dutasteride and topical Minoxidil and Finasteride.

community Another mechanism to hair loss that isn’t talked about. Heavy metals and follicle waste.

16 upvotes 2 months ago

Hair follicles can store waste, potentially leading to hair loss, and treatments like DHT blockers and Minoxidil are suggested. Scalp inflammation and sensitivity to DHT also contribute to hair loss, and addressing these factors with a clinician is recommended.

community What Are the Technicalities of Curved Hair Transplantation?

4 upvotes 5 months ago

Curved hair transplantation requires specialized tools and techniques to avoid damaging hair follicles, with modified FUE being the preferred method. Proper extraction and implantation angles are crucial to prevent complications like keloids and sterile folliculitis.

community 3 months on Finasteride — my honest experience

471 upvotes 2 months ago

The user shared their experience with finasteride, noting initial side effects like weaker erections and anxiety, which improved over time as they recognized the nocebo effect. They emphasized that anxiety can amplify perceived side effects, and encouraged others to consider this when evaluating their own experiences with the medication.

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