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    Glossary5α-reductase deficiency (5AR deficiency)

    genetic condition impairing testosterone conversion to dihydrotestosterone (DHT)

    5α-reductase deficiency is a genetic condition where the body lacks sufficient levels of the enzyme 5α-reductase, which is crucial for converting testosterone into dihydrotestosterone (DHT). This deficiency can lead to atypical development of male genitalia in utero and can affect secondary sexual characteristics during puberty.

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      learn Dutasteride

      Heavy duty finasteride that comes with higher risks, but scalp injections seem safe and are gaining popularity

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      Androgens and Alopecia

      research Androgens and Alopecia

      165 citations, December 2002 in “Molecular and Cellular Endocrinology”
      Male hormones, particularly DHT, are linked to male pattern hair loss, and treatments like finasteride can help, but they don't work for postmenopausal women's hair loss, which may have different causes.
      Novel Inhibitors of 5α-Reductase

      research Novel Inhibitors of 5α-Reductase

      20 citations, February 2002 in “Expert Opinion on Therapeutic Patents”
      New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.
      Clinical Use of 5α-Reductase Inhibitors

      research Clinical Use of 5α-Reductase Inhibitors

      3 citations, January 2001 in “Cambridge University Press eBooks”
      Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.

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