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Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

research Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia

11 citations , September 1997 in “Archives of Dermatology”

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

research Novel type 1 5a-reductase Inhibitors with Antiproliferative Potential on LNCaP cells

June 2023 in “Oriental Journal of Chemistry/Oriental journal of chemistry”

This study demonstrated that derivatives of dehydroepiandrosterone (2a-b, 3a-f, and 4a-f) significantly reduced viable LNCaP prostate cancer cells, suggesting potential therapeutic use for metastatic prostate cancer, while finasteride did not alter cell viability.

research The human skin as a hormone target and an endocrine gland

146 citations , January 2004 in “Hormones”

This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.

Overexpression of Aldo-Keto Reductase 1C3 in LNCaP Cells Diverts Androgen Metabolism Towards Testosterone Resulting in Resistance to the 5α-Reductase Inhibitor Finasteride

research Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

45 citations , January 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.

Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay

research Identification of a new plant extract for androgenic alopecia treatment using a non-radioactive human hair dermal papilla cell-based assay

17 citations , December 2015 in “BMC Complementary and Alternative Medicine”

This study found that Avicennia marina extract significantly inhibited 5α-reductase type 1 activity in human hair dermal papilla cells, suggesting its potential use for treating androgenic alopecia.

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learn dehydroepiandrosterone

learn Alfatradiol

a synthetic estrogen used topically as an anti-androgen

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

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community Testosterone and Estradiol levels on 1 mg/day dutasteride

43 upvotes 11 months ago

A 30-year-old man experienced significant hair regrowth and improved libido after using finasteride and dutasteride for androgenetic alopecia, with no adverse effects. He plans to reduce dutasteride dosage when trying to conceive and has been using topical minoxidil since 2015.

community DIY Testosterone replacement therapy and fin

15 upvotes 4 months ago

An 18-year-old is considering testosterone replacement therapy with finasteride or dutasteride for hair loss but worries about side effects. Users recommend alternatives like minoxidil, RU58841, and consulting a doctor.

community M-28, did a few hormone blood tests since I want a baseline before starting Fin. DhT high. But also Estradiol? Why?

4 upvotes 5 years ago

A user discusses their hormone blood test results before starting finasteride for hair loss, noting high DHT and estradiol levels. They tried topical finasteride for a few days but felt tired.

community Hormone test results - anybody else have similar with fin/dut

7 upvotes 2 months ago

A user on Finasteride for 7-8 years reported unexpectedly high testosterone levels despite expecting lower levels due to age, with discussions on the impact of SHBG and suggestions to use boron to lower SHBG. Another user noted that Dutasteride significantly increased their testosterone and free testosterone levels.

community What hormones should I have tested at a minimum before starting a DHT blocker or anti-androgen?

4 upvotes 2 years ago

The conversation is about someone planning to start finasteride or RU58841 for hair loss and wanting to know which hormones to test beforehand. They found a package for testing testosterone, free testosterone, estradiol, and DHT, and are asking if these tests are enough.

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