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Dutasteride, A Novel Dual 5-Alpha Reductase Inhibitor, Reduces Serum DHT to a Greater Extent Versus Finasteride and Achieves Maximal Reduction in a Larger Proportion of Patients

research Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients

12 citations , February 2003 in “European Urology Supplements”

Dutasteride reduces DHT more effectively than finasteride.

research 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice

7 citations , January 2013 in “European Urology”

This study developed solid lipid nanoparticles for delivering a shRNA-encoding plasmid that effectively reduced 5α-reductase enzyme levels in vitro without significant cytotoxicity, suggesting potential therapeutic applications.

Oral Testosterone in Oil: Pharmacokinetic Effects of 5α-Reduction by Finasteride or Dutasteride and Food Intake in Men

research Oral Testosterone in Oil: Pharmacokinetic Effects of 5 Reduction by Finasteride or Dutasteride and Food Intake in Men

22 citations , January 2006 in “International Journal of Andrology”

This study found that coadministration of 5α-reductase inhibitors with oral testosterone in oil significantly increases serum testosterone levels in medically castrated men compared to testosterone alone, with food intake minimally affecting these levels.

research Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study reports that structural and biochemical analysis of steroid 5α-reductases clarifies how they mediate steroid reduction with NADPH, potentially aiding in designing targeted therapies.

In Vivo Time-Dependent Inhibition of Human Steroid 5α-Reductase by Finasteride

research In Vivo Time-Dependent Inhibition of Human Steroid 5a-Reductase by Finasteride

29 citations , January 1996 in “Journal of Pharmaceutical Sciences”

This study developed a theoretical model that suggests finasteride may completely inhibit 5AR type 2, but not sufficiently suppress type 1, leading to only partial reduction of dihydrotestosterone at clinical doses.

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community Finasteride affects both 5a reductase and 5b reductase

8 upvotes 7 years ago

Finasteride not only inactivates the 5a reductase enzyme but also affects the 5b reductase enzyme in a dose-dependent manner, which can impact sexual behavior and brain activity. The user experienced significant hair regrowth and side effects on 1mg of finasteride, which diminished after reducing the dose to 0.5mg, leading to no side effects and further hair improvement.

community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.

in Research/Science 9 upvotes 3 years ago

Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.

community Supposedly dairy contains precursors to DHT that are already 5a-reduced and convert to DHT independent of 5a-reductase inhibition

26 upvotes 5 months ago

Dairy may contain DHT precursors that could affect hair loss and prostate health, with some users noting reduced hair shedding after eliminating dairy. Individual responses to dairy and DHT blockers vary, with some attributing hair health to diet changes and others seeing no impact.

community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

15 upvotes 5 months ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

community Approximation of Scalp DHT Suppression Between 0.05 mg to 2.5 mg

in Research/Science 63 upvotes 2 years ago

The conversation discusses the effectiveness of various doses of Dutasteride in reducing scalp DHT and its impact on hair count. Users shared personal experiences with hair loss treatments, including Dutasteride, Finasteride, and Minoxidil, with one reporting significant hair loss reduction using a combination of oral Dutasteride and topical Minoxidil and Finasteride.

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