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Glossary5α-reductase

enzyme converting testosterone into potent dihydrotestosterone (DHT)

5α-reductase is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen hormone. This enzyme plays a significant role in various biological processes, including the development of male characteristics and the regulation of hair growth. Inhibitors of 5α-reductase, such as finasteride, are commonly used to treat conditions like male pattern baldness and benign prostatic hyperplasia.

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Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

research Physiopathological Role of the Enzymatic Complex 5α-Reductase and 3α/β-Hydroxysteroid Oxidoreductase in the Generation of Progesterone and Testosterone Neuroactive Metabolites

18 citations, March 2020 in “Frontiers in Neuroendocrinology”

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

research Skin Steroidogenesis in Health and Disease

47 citations, September 2016 in “Reviews in endocrine and metabolic disorders”

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

research Effects of Camellia Oleifera Seed Shell Polyphenols and 1,3,6-Tri-O-Galloylglucose on Androgenic Alopecia via Inhibiting 5α-Reductase and Regulating Wnt/β-Catenin Pathway

September 2024 in “Fitoterapia”

Camellia oleifera seed shell polyphenols and 1,3,6-tri-O-galloylglucose can help treat hair loss by reducing certain hormones and promoting hair growth.

research Phytochemicals: An Herbal Remedy for Alopecia

February 2024 in “International journal of biology, pharmacy and allied sciences”

Plant-based treatments can effectively and safely treat hair loss.

research Steroid 5α-Reductase 2 Deficiency Leads to Reduced Dominance-Related and Impulse-Control Behaviors

14 citations, February 2018 in “Psychoneuroendocrinology”

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

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community My muscles & butt are disappearing on finas, and I’m only taking it because my hair was vanishing too. Help! Details below.

in Finasteride/Dutasteride 7 upvotes 3 years ago

A 39 year old female who has been taking finasteride for 1.5 months and is experiencing side effects such as muscle and butt shrinkage, and weight loss despite still having tight clothing. The user is seeking advice from those with knowledge of bodybuilding and hormones to help figure out the issue.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Started taking 2.5mg Dut about a month ago

in Technology 17 upvotes 5 months ago

A user started taking 2.5mg Dutasteride for hair loss, along with oral Minoxidil, and is concerned about liver impact. Other users warn about the high dosage and potential health risks.

community Meta analysis: Topical or mesotherapy dutasteride is more effective than topical finasteride in the treatment of AGA in men

in Research/Science 19 upvotes 2 years ago

Topical Dutasteride is more effective than topical Finasteride for treating AGA in men, with fewer side effects. Mesotherapy with Dutasteride, administered every 3 months, shows promising results for hair regrowth and maintenance without daily routines or significant side effects.

community From the research study: "Dihydrotestosterone and the concept of 5a-reductase inhibition in human benign prostatic hyperplasia" - G. Bartsch, R.S. Rittmaster, H. Klocker (2002) in the "World Journal of Urology".

in Research/Science 23 upvotes 2 years ago

Dutasteride is a stronger 5AR inhibitor than finasteride and can significantly lower DHT levels. Reduced doses of dutasteride may lower side effects.

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