research Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats
This study found that exercise decreases the expression of 5αR1, thereby enhancing the PI3K/AKT signaling pathway in PCOS rats.
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5 / 1000+ results research Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2
This study evaluated novel steroid compounds for their ability to inhibit 5α-reductase, showing that compound 16a significantly reduced rat prostate weight more than epristeride and exhibited excellent in vitro inhibitory potency, indicating its potential as a lead candidate for further benign prostatic hyperplasia drug research.
research In silico screening of effective inhibitor of 5α-reductase type 1 for androgenic alopecia treatment
In this study, in silico screening and molecular simulations identified β-sitosterol and brassicasterol as stable potential inhibitors of 5α-reductase1, suggesting they could be explored for androgenic alopecia treatment.
research Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2
This study found that aliphatic ester moieties in 16-formyl-17-methoxy dehydroepiandrosterone derivatives increased their potency as 5α-reductase type 2 inhibitors in vitro compared to finasteride.
research LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.
This study identified LY191704 as a specific noncompetitive inhibitor of human 5 alpha-reductase type 1, which may be useful in treating endocrine disorders related to DHT overproduction.
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5 / 1000+ resultscommunity 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?
Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.
community Did anybody use beta sisterol for hair loss? I saw in many articles in the internet that said that beta sisterol blocks dht by inhibiting 5a reductase type 2 enzyme and some reviews of people who said that it worked better than saw palmetto in terms of stoping hair loss and helping prostate.
Beta-sitosterol may inhibit 5-alpha reductase type 2 enzyme, potentially reducing DHT levels and promoting hair growth, similar to finasteride but possibly with fewer side effects. Its effectiveness and side effects compared to other treatments like saw palmetto and finasteride remain uncertain due to limited research.
community Was scared to try fin and jumped straight to 2.5mg Dut?
The user started with oral minoxidil and switched to 2.5mg dutasteride, experiencing significant hair growth without side effects. They believe dutasteride has fewer side effects than finasteride due to its action on both type 1 and 2 5-alpha reductase enzymes.
community We need actual hair loss studies on Epristeride
Epristeride is a selective 5 alpha reductase type 2 inhibitor that may reduce scalp DHT similarly to finasteride, with potentially fewer side effects. It is suggested that combining epristeride with finasteride or dutasteride could enhance hair loss treatment effectiveness.
community Dutasteride might be better for your hairline. Some people have more type 1 5AR activity in their scalp than others.
Dutasteride might be better for hairline due to varying levels of 5AR activity in scalps. Genetic tests can determine if finasteride is enough or if dutasteride is needed.
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5 / 801 resultslearn Dutasteride
Heavy duty finasteride that comes with higher risks
learn Stem Cell Factor
learn Osteopontin
signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss
learn Overview
learn Finasteride
Frontline, gold standard treatment for combatting androgenic alopecia
Experts
6 / 9 results- 25
SMP SpecialistKelsey Tyre
Wilmington, DE, United States
- 33
Hair Transplant SurgeonDr. Tapeshwar Sehgal, MD
Hisar, Haryana, India
- 35Hair System Specialist
Tye Brock Meredith
Redding, CA, United States
- 87SMP Specialist
Tyler Bennet
Las Vegas, NV, United States
- 14SMP Specialist
Tyler
Incomplete name
Calgary, AB, Canada
- 41SMP Specialist
Tyler Robertson
Fort Wayne, IN, United States
Clinics
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Hair TransplantSynergenX Tyler | Hormone Health & TRT ClinicTyler, TX · US - 33
Hair Loss TreatmentsHair SystemsTupelo Hair LossTupelo, MS · US - 20Hair Loss TreatmentsIt's A Secret Med Spa - TylerTyler, TX · US
- 24
Hair SystemsTUPELUCAOrihuela, Comunitat Valenciana · ES - 29Hair SystemsTopee Hair PatchesBengaluru, Karnataka · IN
- 34
Hair Loss TreatmentsTye & Company Salon & Hair Loss StudioBaltimore, MD · US