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Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.

Prominin-1 expressing cells in the dermal papilla help regulate hair follicle size and communication but don't aid in skin repair.

Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.