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Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations, June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research New Insights Into Testosterone Biosynthesis: Novel Observations From HSD17B3 Deficient Mice

8 citations, December 2022 in “International journal of molecular sciences”

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

research The Impact of the 5α-Reductase Inhibitors on Male Sexual Function and Psychological Well-Being

1 citations, August 2015 in “Current Sexual Health Reports”

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

research Androgens and Ovarian Function: Translation from Basic Discovery Research to Clinical Impact

55 citations, May 2019 in “Journal of Endocrinology”

Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.

research Endocrinology Overview: Male Reproductive Endocrinology and HPT Axis

January 2018 in “Elsevier eBooks”

The document explains how male reproductive hormones work and affect the body.

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Community Join

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community u/joaopassos4444 has zero education in endocrinology, human biology or science, it’s incredibly unlikely he good Will Hunting-ed a medical issue that stumped researchers for thousands of years, please stop buying random supplements based on layman speculation and temper your expectations

-CygnusVismundCygnus in Research/Science 69 upvotes 3 years ago

User questions credibility of a hair loss "cure" found by a non-expert and warns against wasting money on unproven supplements. Others discuss trying natural extracts and the importance of researching the enzyme 3ADH for potential hair growth benefits.

community UPDATE: The theory that explains everything. Please help me make this big!

joaopassos4444 in Research/Science 448 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community 22 years since the last major development

heraldomalso in Technology 50 upvotes 3 years ago

The conversation discusses the lack of significant advancements in hair loss treatments since the introduction of finasteride 22 years ago, with many expressing frustration over the failure of new projects and skepticism about future developments. Some users mention hair transplants and other potential alternatives like Alfatradiol and Fluridil, but acknowledge finasteride's dominance in the market due to its effectiveness and affordability.

community U/joaopassos444 , HATS OFF brother !!

LegFriendly9957 in Research/Science 126 upvotes 3 years ago

A new hair loss treatment theory beyond minoxidil and finasteride is proposed, causing mixed reactions in the community, with some members eager to explore and support it, while others call for more research and evidence.

community The theory that explains everything. Please help me make this big!

joaopassos4444 in Research/Science 2453 upvotes 3 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

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