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research Development of Novel Mitochondrial Pyruvate Carrier Inhibitors to Treat Hair Loss

33 citations , February 2021 in “Journal of Medicinal Chemistry”

This study found that novel MPC inhibitor analogues with specific chemical modifications promoted significant hair growth in shaved mice when applied topically.

research AN EFFICIENT SYNTHESIS OF DUTASTERIDE: UTILIZING BENZOYL GROUP AS NOVEL LACTAMIC PROTECTING GROUP

January 2017 in “Rasayan journal of Chemistry”

This paper describes a new scalable synthesis method for Dutasteride, highlighting its potential for large-scale commercial production.

research Novel inhibitors of 5α-reductase

20 citations , February 2002 in “Expert Opinion on Therapeutic Patents”

This review discusses the potential uses of 5α-reductase inhibitors for conditions ranging from benign prostatic hyperplasia to skin disorders like acne and male pattern baldness, but it reports no new clinical results.

research A Review on Steroidal 5α-Reductase Inhibitors for Treatment of Benign Prostatic Hyperplasia

17 citations , August 2011 in “Current Medicinal Chemistry”

This review summarizes recent advancements in steroidal 5α-reductase inhibitors for benign prostatic hyperplasia and reports no new clinical results.

research Action Mechanism of Extracts from Cerasus serrulata Flower for Hair-Blacking in C57BL/6 Mice

April 2023 in “Pharmacognosy Magazine”

In a study using a mouse model, Cerasus serrulata flower extracts significantly increased β-catenin and VEGF expression, promoting hair blackening and suggesting potential as a treatment for premature greying.

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community EveryChem 3HP / PP30 page data vs NMR PDFs in their website : metadata mistake or document mismatch?

in Research/Science 15 upvotes 5 months ago

There is an inconsistency between the molecular weight and formula listed on EveryChem's product page and the analytical PDFs for 3HP and PP30, suggesting a possible error in the product description. Concerns are raised about EveryChem's business practices and lack of transparency in testing and manufacturing.

community Has anyone ordered JXL-069 (grey market PP405)?

53 upvotes 1 year ago

People are discussing JXL-069 (PP405) for hair loss, with some experimenting with a 0.05% topical gel. Concerns about safety and efficacy persist due to limited testing and lack of official approval.

community PP405 gets its generic name - Suvomipic

287 upvotes 2 months ago

Suvomipic, previously known as PP405, is progressing to Phase 3 trials for hair loss treatment. Its effectiveness compared to existing treatments like Minoxidil and Finasteride is still uncertain.

community PP405 Identity Research

in Research 292 upvotes 1 year ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community The truth about Dutasteride (w/ sources)

in Finasteride/Dutasteride 52 upvotes 3 years ago

The effectiveness of Dutasteride compared to Finasteride in treating hair loss, with evidence given such as studies and experiences, as well as discussion around whether one should switch from Finasteride to Dutasteride. There is also a discussion on post-Dutasteride syndrome.

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