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Research

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research Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis

138 citations , April 2003 in “Carcinogenesis”

This study found that 2-methoxyestradiol induces apoptosis in human prostate cancer cells by activating p53 through a pathway dependent on p38/JNK-mediated NFkappaB/AP-1 activation, with JNK-dependent Bcl-2 phosphorylation also playing a critical role.

Differential Activity of 2-Methylene-19-Nor Vitamin D Analogs on Growth Factor Gene Expression in Rhino Mouse Skin and Comparison to All-Trans Retinoic Acid

research Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid

2 citations , November 2017 in “PloS one”

This study found that 2MbisP increases epidermal thickening more rapidly than atRA in rhino mice, while both compounds similarly reduce utricle size.

research Preparation, Characterization and Molecular Docking Study of some New Pyrazole Derivatives Derived from 2-Mercaptobenzothiazole.

June 2025 in “Mağallaẗ ʻulūm al-rāfidayn”

This study found that certain pyrazole derivatives may serve as effective 5α-reductase inhibitors with potential use in the treatment of androgenetic alopecia, based on molecular docking analyses.

Effect of Metformin Using 2-Hour Postload Insulin for Measuring Insulin Resistance in Taiwanese Women with Polycystic Ovary Syndrome

research Effect of metformin by employing 2-hour postload insulin for measuring insulin resistance in Taiwanese women with polycystic ovary syndrome

6 citations , April 2016 in “Journal of the Formosan Medical Association”

This study found that metformin treatment improved clinical outcomes in Taiwanese women with polycystic ovary syndrome, notably in overweight and insulin-resistant patients.

research 2‐Deoxy‐d‐glucose enhances tonic inhibition through the neurosteroid‐mediated activation of extrasynaptic GABA_A receptors

44 citations , October 2016 in “Epilepsia”

This study demonstrated that the glycolytic inhibitor 2-deoxy-D-glucose enhances antiseizure effects by potentiating extrasynaptic tonic GABAergic inhibition through neurosteroidogenesis in hippocampal slices.

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Community Join

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community 2 years of me being on fin+min

in Progress Pictures 1216 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically the use of oral finasteride and topical minoxidil, with the user sharing their two-year progress and routine. The user experienced initial shedding but saw improvements after six months, and they recently started taking dutasteride.

community 2 years on meds and micro- needling

331 upvotes 1 year ago

The user has been using minoxidil, finasteride, and microneedling for two years, resulting in significant hair regrowth and plans for a 4000 graft hair transplant. The treatments have strengthened the donor area, making a hair transplant feasible.

community Officially 2 years on meds, looking for HT advice

in Progress Pictures 5 upvotes 1 month ago

The user has been using topical minoxidil, finasteride, and dutasteride for hair loss, with plans to consider a hair transplant. They are advised that 2500-3000 grafts might be needed for desired density.

community My 2-Year Journey – Meds Finally Kicking In

345 upvotes 10 months ago

The user experienced significant hair regrowth and reduced shedding after two years of using finasteride, minoxidil, and a laser helmet, along with maintaining scalp health with specific shampoos. Consistency and patience were key to their success, despite initial heavy shedding.

community 2 months of Oral .5 Fin 2.5 Min - Let me know your thoughts!

in Is this regrowth? 160 upvotes 1 year ago

The user is experiencing positive hair regrowth after two months of using oral finasteride (0.5 mg) and minoxidil (2.5 mg) and is considering a hair transplant. They are seeking advice on surgeons closer to the U.S. and discussing potential side effects and alternative treatments.

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Learn

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learn Hair Transplant

How does a hair transplant differ between men and women? Hair transplants for men focus on hairline restoration, while women prioritize density.
What are the different hair transplant techniques? The main hair transplant techniques are FUE, DHI, and FUT, each with unique benefits.
When can I wash my hair after a hair transplant? Wash your hair gently 24 to 72 hours after a hair transplant.