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Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

research Large-Scale Genome-Wide Meta-Analysis of Polycystic Ovary Syndrome Suggests Shared Genetic Architecture for Different Diagnosis Criteria

308 citations , December 2018 in “PLOS Genetics”

The research found that PCOS has common genetic factors regardless of how it is diagnosed and is linked to metabolic and reproductive issues.

research Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases

87 citations , May 2012 in “PLOS Genetics”

Six new genetic regions linked to early hair loss also connect to Parkinson's disease and prostate cancer, possibly leading to new treatments.

research A Folliculocentric Perspective of Dandruff Pathogenesis: Could a Troublesome Condition Be Caused by Changes to a Natural Secretory Mechanism?

3 citations , September 2021 in “BioEssays”

Dandruff might be caused by changes in how hair follicles naturally release oils and an immune response to this imbalance.

research Multi-Ancestry Tandem Repeat Association Study of Hair Color Using Exome-Wide Sequencing

February 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

Tandem repeats significantly influence hair color, especially darker shades, across different ancestries.

research Genome-Wide Association Meta-Analysis of Individuals of European Ancestry Identifies New Loci Explaining a Substantial Fraction of Hair Color Variation and Heritability

94 citations , April 2018 in “Nature Genetics”

New genetic locations explain much of hair color variation in Europeans.

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Community Join

5 / 14 results

community back when I would frequent this subreddit a lot I used to see a lot of negativity. As someone who has moved on I felt it was time to come back and offer some hope.

26 upvotes 8 years ago

A user shared their experience with hair loss treatments, including finasteride and minoxidil, which caused side effects and didn't yield satisfactory results. They eventually shaved their head, found it liberating, and encouraged others to embrace baldness.

community Using 23andme to insight minoxidil response / SULT1A1 activity

in Minoxidil 10 upvotes 4 years ago

The conversation discusses using 23andme to determine if someone might respond well to minoxidil for hair loss treatment, and mentions the user's personal experience with micro-needling and minoxidil.

community Serum DHT data wanted for insights into dutasteride efficacy. Please get in touch!

gnathan in General 132 upvotes 1 year ago

The conversation is about gathering serum DHT data from individuals taking dutasteride to investigate its efficacy, especially in cases with unexpectedly low DHT reduction. The aim is to explore potential genetic factors affecting drug metabolism.

community Minoxidil Response Test - worth it?

in Minoxidil 9 upvotes 1 year ago

The conversation discusses the use of topical minoxidil for hair loss and the potential benefits of taking a Minoxidil Response Test to determine enzyme activity related to its effectiveness. Some users have considered or tried alternatives like oral minoxidil or tretinoin, with mixed experiences regarding side effects and effectiveness.

community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 6 months ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

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