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PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

The user shared their experience with oral finasteride and minoxidil for hair loss, noting initial improvement but experiencing setbacks after inconsistent use. Despite resuming the medication, they faced renewed shedding and are seeking insights into the fluctuating progress.

The user is happy with the progress of using oral finasteride and minoxidil for hair loss over nearly a year, despite experiencing some shedding and concerns about hair density. They also use keto shampoo weekly and have fallen behind on derma stamping.

The user maintained their hair at Norwood 2 using finasteride, starting with 0.5mg and increasing to 1mg daily, and recently switched to dutasteride for potential regrowth. They experienced no significant side effects and have not yet used minoxidil.

The user has been using topical minoxidil and finasteride for hair regrowth but is experiencing slow or no regrowth on certain areas. Suggestions include switching to oral minoxidil and possibly dutasteride, with some users recommending microneedling and others cautioning against aggressive DHT suppression due to potential side effects.