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Glossary17β-Hydroxysteroid Dehydrogenase (17beta-HSD)

enzyme that converts weaker sex hormones into more potent ones

17β-Hydroxysteroid Dehydrogenase (17β-HSD) is an enzyme that plays a crucial role in the metabolism of steroids, including the conversion of weaker sex hormones into more potent ones. For example, it can convert androstenedione to testosterone and estrone to estradiol, which are important processes in regulating various physiological functions such as reproduction, hair growth, and overall hormonal balance.

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research Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids

26 citations , March 2006 in “Endocrine, metabolic & immune disorders. Drug targets”

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

research Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma

1 citations , January 2017 in “Tohoku journal of experimental medicine”

A woman's mature cystic teratoma caused her virilization by producing testosterone.

research Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells

63 citations , November 1999 in “British journal of dermatology/British journal of dermatology, Supplement”

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

research Influence of Estrogens on Androgen Metabolism in Different Subunits of Human Hair Follicles

41 citations , July 2001 in “PubMed”

Estrogens can reduce DHT production in hair follicles, but are less effective than finasteride and progesterone.

Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

5 citations , July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

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community 1 year Progress: Fin + Oral Min 5mg

in Progress Pictures 407 upvotes 3 years ago

A user's experience with finasteride and oral minoxidil for treating hair loss, which resulted in great regrowth and improved mental state. Other users asked questions about their own experiences with the treatments.

community Estradiol (E2), Testosterone and DHT levels after 1 month on Dutasteride

in Research/Science 12 upvotes 1 year ago

Dutasteride and finasteride are used for hair loss, affecting hormone levels like DHT and testosterone. Hormone balance is crucial, as changes can lead to side effects such as increased estradiol and potential hair loss.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 13 upvotes 1 year ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community 16 months finasteride progress but slowly losing hair again

in Progress Pictures 137 upvotes 10 months ago

A 21-year-old male experienced initial success with finasteride for 16 months but is now losing hair again. He is considering switching to dutasteride and adding oral minoxidil, while also investigating environmental and health factors.

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

in Finasteride/Dutasteride 183 upvotes 1 year ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

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