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Glossary17β-Hydroxysteroid Dehydrogenase (17beta-HSD)

enzyme that converts weaker sex hormones into more potent ones

17β-Hydroxysteroid Dehydrogenase (17β-HSD) is an enzyme that plays a crucial role in the metabolism of steroids, including the conversion of weaker sex hormones into more potent ones. For example, it can convert androstenedione to testosterone and estrone to estradiol, which are important processes in regulating various physiological functions such as reproduction, hair growth, and overall hormonal balance.

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research Roles of Type 10 17beta-Hydroxysteroid Dehydrogenase in Intracrinology and Metabolism of Isoleucine and Fatty Acids

26 citations, March 2006 in “Endocrine, metabolic & immune disorders. Drug targets”

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

research Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma

1 citations, January 2017 in “Tohoku journal of experimental medicine”

A woman's mature cystic teratoma caused her virilization by producing testosterone.

research Expression of mRNA for Androgen Receptor, 5α-Reductase, and 17β-Hydroxysteroid Dehydrogenase in Human Dermal Papilla Cells

63 citations, November 1999 in “British journal of dermatology/British journal of dermatology, Supplement”

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

research Glioblastoma Cells Express Crucial Enzymes Involved in Androgen Synthesis: 3β-Hydroxysteroid Dehydrogenase, 17-20α-Hydroxylase, 17β-Hydroxysteroid Dehydrogenase, and 5α-Reductase

5 citations, July 2021 in “Endocrinology, diabetes & metabolism”

Glioblastoma cells can make androgens, which might help the tumor grow.

research Skin Steroidogenesis in Health and Disease

47 citations, September 2016 in “Reviews in endocrine and metabolic disorders”

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

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community 1 year Progress: Fin + Oral Min 5mg

in Progress Pictures 407 upvotes 2 years ago

A user's experience with finasteride and oral minoxidil for treating hair loss, which resulted in great regrowth and improved mental state. Other users asked questions about their own experiences with the treatments.

community Estradiol (E2), Testosterone and DHT levels after 1 month on Dutasteride

in Research/Science 13 upvotes 3 weeks ago

Dutasteride and finasteride are used for hair loss, affecting hormone levels like DHT and testosterone. Hormone balance is crucial, as changes can lead to side effects such as increased estradiol and potential hair loss.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 6 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community My DHT levels have increased after taking 0.25mg Fin for 47 days!

in Finasteride/Dutasteride 185 upvotes 1 month ago

A user experienced increased hair shedding and unchanged DHT levels after taking 0.25mg of finasteride for 47 days, leading them to increase the dose to 0.5mg. Others discussed varying experiences with finasteride, minoxidil, and the importance of measuring scalp DHT.

community Creatine's effect on Hair Loss and DHT

in Research/Science 102 upvotes 9 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

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